Lymphocyte radiosensitivity is a significant prognostic factor for morbidity in carcinoma of the cervix.
dc.contributor.author | West, Catharine M L | |
dc.contributor.author | Davidson, Susan E | |
dc.contributor.author | Elyan, S A | |
dc.contributor.author | Valentine, Helen R | |
dc.contributor.author | Roberts, Stephen A | |
dc.contributor.author | Swindell, Ric | |
dc.contributor.author | Hunter, Robin D | |
dc.date.accessioned | 2009-10-13T11:01:16Z | |
dc.date.available | 2009-10-13T11:01:16Z | |
dc.date.issued | 2001-09-01 | |
dc.identifier.citation | Lymphocyte radiosensitivity is a significant prognostic factor for morbidity in carcinoma of the cervix. 2001, 51 (1):10-5 Int. J. Radiat. Oncol. Biol. Phys. | en |
dc.identifier.issn | 0360-3016 | |
dc.identifier.pmid | 11516845 | |
dc.identifier.uri | http://hdl.handle.net/10541/84150 | |
dc.description.abstract | PURPOSE: To study the relationship between pretreatment peripheral blood lymphocyte radiosensitivity and morbidity following radiation therapy. METHODS AND MATERIALS: A prospective study was carried out in which patients with carcinoma of the cervix underwent radiation therapy. Intrinsic radiosensitivity was measured on pretreatment peripheral blood lymphocytes, using a limiting dilution clonogenic assay. Late morbidity was assessed using the Franco-Italian glossary. Results were correlated in an actuarial analysis. RESULTS: There were no correlations between the measured lymphocyte radiosensitivity (SF2) and colony-forming efficiency, patient age, tumor grade, or disease stage. For 83 patients, lymphocyte SF2 was a significant prognostic factor for the probability of developing both any (p = 0.002) and Grade 3 (p = 0.026) morbidity. In 174 patients, stage showed borderline significance as a prognostic factor for morbidity (p = 0.056). However, the type of treatment (intracavitary alone, intracavitary plus parametrial irradiation, single insertion plus whole-pelvis irradiation) was significantly associated with the probability of developing late complications (p = 0.013). There was a weak significant inverse correlation between lymphocyte SF2 and grade of morbidity (r = -0.34, p = 0.002). CONCLUSION: These data highlight the importance of normal cell radiosensitivity as a factor determining radiation therapy response. They also show that peripheral blood lymphocyte SF2 is a highly significant prognostic factor for the probability of developing late radiation morbidity, and that carcinoma of the cervix is a good model for testing radiobiologic principles in the clinic. | |
dc.language.iso | en | en |
dc.subject | Cancer Staging | en |
dc.subject | Uterine Cervical Cancer | en |
dc.subject.mesh | Age Factors | |
dc.subject.mesh | Brachytherapy | |
dc.subject.mesh | Carcinoma | |
dc.subject.mesh | Cell Survival | |
dc.subject.mesh | Colony-Forming Units Assay | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Lymphocytes | |
dc.subject.mesh | Neoplasm Staging | |
dc.subject.mesh | Probability | |
dc.subject.mesh | Prognosis | |
dc.subject.mesh | Prospective Studies | |
dc.subject.mesh | Radiation Injuries | |
dc.subject.mesh | Radiation Tolerance | |
dc.subject.mesh | Uterine Cervical Neoplasms | |
dc.title | Lymphocyte radiosensitivity is a significant prognostic factor for morbidity in carcinoma of the cervix. | en |
dc.type | Article | en |
dc.contributor.department | CRC Experimental Radiation Oncology Group, Paterson Institute for Cancer Research, Manchester, United Kingdom. cwest@picr.man.ac.uk | en |
dc.identifier.journal | International Journal of Radiation Oncology, Biology, Physics | en |
html.description.abstract | PURPOSE: To study the relationship between pretreatment peripheral blood lymphocyte radiosensitivity and morbidity following radiation therapy. METHODS AND MATERIALS: A prospective study was carried out in which patients with carcinoma of the cervix underwent radiation therapy. Intrinsic radiosensitivity was measured on pretreatment peripheral blood lymphocytes, using a limiting dilution clonogenic assay. Late morbidity was assessed using the Franco-Italian glossary. Results were correlated in an actuarial analysis. RESULTS: There were no correlations between the measured lymphocyte radiosensitivity (SF2) and colony-forming efficiency, patient age, tumor grade, or disease stage. For 83 patients, lymphocyte SF2 was a significant prognostic factor for the probability of developing both any (p = 0.002) and Grade 3 (p = 0.026) morbidity. In 174 patients, stage showed borderline significance as a prognostic factor for morbidity (p = 0.056). However, the type of treatment (intracavitary alone, intracavitary plus parametrial irradiation, single insertion plus whole-pelvis irradiation) was significantly associated with the probability of developing late complications (p = 0.013). There was a weak significant inverse correlation between lymphocyte SF2 and grade of morbidity (r = -0.34, p = 0.002). CONCLUSION: These data highlight the importance of normal cell radiosensitivity as a factor determining radiation therapy response. They also show that peripheral blood lymphocyte SF2 is a highly significant prognostic factor for the probability of developing late radiation morbidity, and that carcinoma of the cervix is a good model for testing radiobiologic principles in the clinic. |