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dc.contributor.authorWest, Catharine M L
dc.contributor.authorDavidson, Susan E
dc.contributor.authorElyan, S A
dc.contributor.authorValentine, Helen R
dc.contributor.authorRoberts, Stephen A
dc.contributor.authorSwindell, Ric
dc.contributor.authorHunter, Robin D
dc.date.accessioned2009-10-13T11:01:16Z
dc.date.available2009-10-13T11:01:16Z
dc.date.issued2001-09-01
dc.identifier.citationLymphocyte radiosensitivity is a significant prognostic factor for morbidity in carcinoma of the cervix. 2001, 51 (1):10-5 Int. J. Radiat. Oncol. Biol. Phys.en
dc.identifier.issn0360-3016
dc.identifier.pmid11516845
dc.identifier.urihttp://hdl.handle.net/10541/84150
dc.description.abstractPURPOSE: To study the relationship between pretreatment peripheral blood lymphocyte radiosensitivity and morbidity following radiation therapy. METHODS AND MATERIALS: A prospective study was carried out in which patients with carcinoma of the cervix underwent radiation therapy. Intrinsic radiosensitivity was measured on pretreatment peripheral blood lymphocytes, using a limiting dilution clonogenic assay. Late morbidity was assessed using the Franco-Italian glossary. Results were correlated in an actuarial analysis. RESULTS: There were no correlations between the measured lymphocyte radiosensitivity (SF2) and colony-forming efficiency, patient age, tumor grade, or disease stage. For 83 patients, lymphocyte SF2 was a significant prognostic factor for the probability of developing both any (p = 0.002) and Grade 3 (p = 0.026) morbidity. In 174 patients, stage showed borderline significance as a prognostic factor for morbidity (p = 0.056). However, the type of treatment (intracavitary alone, intracavitary plus parametrial irradiation, single insertion plus whole-pelvis irradiation) was significantly associated with the probability of developing late complications (p = 0.013). There was a weak significant inverse correlation between lymphocyte SF2 and grade of morbidity (r = -0.34, p = 0.002). CONCLUSION: These data highlight the importance of normal cell radiosensitivity as a factor determining radiation therapy response. They also show that peripheral blood lymphocyte SF2 is a highly significant prognostic factor for the probability of developing late radiation morbidity, and that carcinoma of the cervix is a good model for testing radiobiologic principles in the clinic.
dc.language.isoenen
dc.subjectCancer Stagingen
dc.subjectUterine Cervical Canceren
dc.subject.meshAge Factors
dc.subject.meshBrachytherapy
dc.subject.meshCarcinoma
dc.subject.meshCell Survival
dc.subject.meshColony-Forming Units Assay
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLymphocytes
dc.subject.meshNeoplasm Staging
dc.subject.meshProbability
dc.subject.meshPrognosis
dc.subject.meshProspective Studies
dc.subject.meshRadiation Injuries
dc.subject.meshRadiation Tolerance
dc.subject.meshUterine Cervical Neoplasms
dc.titleLymphocyte radiosensitivity is a significant prognostic factor for morbidity in carcinoma of the cervix.en
dc.typeArticleen
dc.contributor.departmentCRC Experimental Radiation Oncology Group, Paterson Institute for Cancer Research, Manchester, United Kingdom. cwest@picr.man.ac.uken
dc.identifier.journalInternational Journal of Radiation Oncology, Biology, Physicsen
html.description.abstractPURPOSE: To study the relationship between pretreatment peripheral blood lymphocyte radiosensitivity and morbidity following radiation therapy. METHODS AND MATERIALS: A prospective study was carried out in which patients with carcinoma of the cervix underwent radiation therapy. Intrinsic radiosensitivity was measured on pretreatment peripheral blood lymphocytes, using a limiting dilution clonogenic assay. Late morbidity was assessed using the Franco-Italian glossary. Results were correlated in an actuarial analysis. RESULTS: There were no correlations between the measured lymphocyte radiosensitivity (SF2) and colony-forming efficiency, patient age, tumor grade, or disease stage. For 83 patients, lymphocyte SF2 was a significant prognostic factor for the probability of developing both any (p = 0.002) and Grade 3 (p = 0.026) morbidity. In 174 patients, stage showed borderline significance as a prognostic factor for morbidity (p = 0.056). However, the type of treatment (intracavitary alone, intracavitary plus parametrial irradiation, single insertion plus whole-pelvis irradiation) was significantly associated with the probability of developing late complications (p = 0.013). There was a weak significant inverse correlation between lymphocyte SF2 and grade of morbidity (r = -0.34, p = 0.002). CONCLUSION: These data highlight the importance of normal cell radiosensitivity as a factor determining radiation therapy response. They also show that peripheral blood lymphocyte SF2 is a highly significant prognostic factor for the probability of developing late radiation morbidity, and that carcinoma of the cervix is a good model for testing radiobiologic principles in the clinic.


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