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    The antioxidant n-acetylcysteine increases 5-fluorouracil activity against colorectal cancer xenografts in nude mice.

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    Authors
    Bach, Simon P
    Williamson, Sarah E
    Marshman, Emma
    Kumar, Shant
    O'Dwyer, Sarah T
    Potten, Christopher S
    Watson, A J
    Affiliation
    Cancer Research Campaign, Department of Epithelial Biology, The Paterson Institute, Christie Hospital, Withington, Manchester M20 4BX, UK. Sbach@picr.man.ac.uk
    Issue Date
    2001
    
    Metadata
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    Abstract
    The antioxidant pyrrolidinedithiocarbamate improves the therapeutic efficacy of 5-fluorouracil (5-FU) against HCT-15 colorectal cancer cell line xenografts in nude mice without increasing toxicity to normal intestinal or hematopoietic tissues. In the current study we have shown that a similar clinically licensed antioxidant, N-acetylcysteine (200 mg/kg), can modulate the activity of 5-FU (120 mg/kg) against HCT-15 tumor xenografts in nude mice. We demonstrate that this effect is accompanied by a sustained elevation in p53-independent apoptosis without accompanying alterations in cell cycle kinetics. Extensive tumor necrosis is also a prominent feature of treatment; however, no significant impairment of neovascularization as assessed by intratumor microvessel density occurred. We believe that the clinical efficacy of N-acetylcysteine as an adjunct to 5-FU in advanced colorectal cancer should be investigated further.
    Citation
    The antioxidant n-acetylcysteine increases 5-fluorouracil activity against colorectal cancer xenografts in nude mice., 5 (1):91-7 J. Gastrointest. Surg.
    Journal
    Journal of Gastrointestinal Surgery
    URI
    http://hdl.handle.net/10541/84148
    PubMed ID
    11309653
    Type
    Article
    Language
    en
    ISSN
    1091-255X
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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