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    Heparan sulfate proteoglycans and cancer.

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    Authors
    Blackhall, Fiona H
    Merry, Catherine L R
    Davies, E June
    Jayson, Gordon C
    Affiliation
    Cancer Research Campaign Department of Medical Oncology, Christie Hospital and Paterson Institute for Cancer Research, Wilmslow Road, Withington, Manchester, M20 4BX, UK.
    Issue Date
    2001-10-19
    
    Metadata
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    Abstract
    Heparan sulfate proteoglycans (HSPGs) are widely distributed in mammalian tissues and involved in a number of processes related to malignancy. They are composed of a core protein to which chains of the glycosaminoglycan, heparan sulfate (HS), are attached. The existence of various classes of core protein, in addition to highly polymorphic HS chains, creates a superfamily of macromolecules with considerable diversity of structure and function. HSPGs interact with many proteins including growth factors, chemokines and structural proteins of the extracellular matrix to influence cell growth, differentiation, and the cellular response to the environment. The recent identification of two inherited syndromes that are associated with an increased cancer risk, and caused by mutations in HSPG-related genes, has intensified interest in these molecules. This review describes our current understanding of HSPGs in cancer and highlights new possibilities for therapeutic control.
    Citation
    Heparan sulfate proteoglycans and cancer. 2001, 85 (8):1094-8 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/84147
    DOI
    10.1054/bjoc.2001.2054
    PubMed ID
    11710818
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    ae974a485f413a2113503eed53cd6c53
    10.1054/bjoc.2001.2054
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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