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    Follicular lymphoid hyperplasia of the hard palate and oral mucosa: report of three cases and a review of the literature.

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    Authors
    Menasce, Lia P
    Shanks, Jonathan H
    Banerjee, Saumitra S
    Harris, Martin
    Affiliation
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    2001-10
    
    Metadata
    Show full item record
    Abstract
    AIMS: To bring to wider attention this uncommon, poorly understood entity which may closely resemble, clinically and morphologically, follicular lymphoma. METHODS AND RESULTS: We report three cases of follicular lymphoid hyperplasia of the hard palate and oral mucosa which caused diagnostic difficulties for the referring pathologists. The clinicopathological features are described and integrated into a review of the 16 previously recorded cases. The condition most commonly presents as a slowly growing mass situated in the posterior hard palate but may present with multicentric oral lesions and lymphadenopathy. Morphologically, it is characterized by a dense follicular lymphoid infiltrate within the lamina propria which may show the classical features of benign reactive hyperplasia, but not uncommonly, indistinct germinal centres, ill-defined mantles and a lack of tingible-body macrophages are features which may lead to an erroneous diagnosis of follicular lymphoma. CONCLUSIONS: Follicular lymphoid hyperplasia of the palate is a poorly recognized entity which is frequently confused with follicular lymphoma. Awareness of the entity combined with the use of immunohistochemistry for immunoglobulin light chains and bcl-2 protein allows a correct diagnosis to be made avoiding extensive investigation and aggressive treatment to the patient.
    Citation
    Follicular lymphoid hyperplasia of the hard palate and oral mucosa: report of three cases and a review of the literature. 2001, 39 (4):353-8 Histopathology
    Journal
    Histopathology
    URI
    http://hdl.handle.net/10541/84079
    PubMed ID
    11683934
    Type
    Article
    Language
    en
    ISSN
    0309-0167
    Collections
    All Christie Publications

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