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dc.contributor.authorBarthel, D
dc.contributor.authorMeineke, F A
dc.contributor.authorPotten, Christopher S
dc.contributor.authorLoeffler, M
dc.date.accessioned2009-10-12T11:42:10Z
dc.date.available2009-10-12T11:42:10Z
dc.date.issued2002-08
dc.identifier.citationA continuum model to analyse spatial cell fluxes from positional labelling data applied to cell migration in oral mucosa. 2002, 35 Suppl 1:48-59 Cell Prolif.en
dc.identifier.issn0960-7722
dc.identifier.pmid12139707
dc.identifier.doihttp://dx.doi.org/10.1046/j.1365-2184.35.s1.5.x
dc.identifier.urihttp://hdl.handle.net/10541/84035
dc.description.abstractA novel method is presented which allows the estimation of the velocity of migrating cells from positional 3HTdR labelling data in spatially organized epithelial tissues. In a continuum approach, wave-like profiles of labelling index (LI) data, which travel away from the basal layer, are followed and compared with experimental LI profiles. The method yields estimates of migration velocity, cell flow, and turnover time. Results for the ventral tongue mucosa in a group of 55 BDF1 mice that were labelled at the same time of the day and culled at different time points within a 24-h period have been analysed. The results show a strong circadian rhythm in the migration velocity and the related parameters.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCell Count
dc.subject.meshCell Movement
dc.subject.meshCircadian Rhythm
dc.subject.meshCytological Techniques
dc.subject.meshEpithelial Cells
dc.subject.meshMice
dc.subject.meshModels, Biological
dc.subject.meshMouth Mucosa
dc.subject.meshThymidine
dc.subject.meshTongue
dc.subject.meshTritium
dc.titleA continuum model to analyse spatial cell fluxes from positional labelling data applied to cell migration in oral mucosa.en
dc.typeArticleen
dc.contributor.departmentUniversity of Leipzig, Institute of Medical Informatics, Statistics & Epidemiology, Liebigstrasse 27, Leipzig D-04103, Germany.en
dc.identifier.journalCell Proliferationen
html.description.abstractA novel method is presented which allows the estimation of the velocity of migrating cells from positional 3HTdR labelling data in spatially organized epithelial tissues. In a continuum approach, wave-like profiles of labelling index (LI) data, which travel away from the basal layer, are followed and compared with experimental LI profiles. The method yields estimates of migration velocity, cell flow, and turnover time. Results for the ventral tongue mucosa in a group of 55 BDF1 mice that were labelled at the same time of the day and culled at different time points within a 24-h period have been analysed. The results show a strong circadian rhythm in the migration velocity and the related parameters.


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