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    A continuum model to analyse spatial cell fluxes from positional labelling data applied to cell migration in oral mucosa.

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    Authors
    Barthel, D
    Meineke, F A
    Potten, Christopher S
    Loeffler, M
    Affiliation
    University of Leipzig, Institute of Medical Informatics, Statistics & Epidemiology, Liebigstrasse 27, Leipzig D-04103, Germany.
    Issue Date
    2002-08
    
    Metadata
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    Abstract
    A novel method is presented which allows the estimation of the velocity of migrating cells from positional 3HTdR labelling data in spatially organized epithelial tissues. In a continuum approach, wave-like profiles of labelling index (LI) data, which travel away from the basal layer, are followed and compared with experimental LI profiles. The method yields estimates of migration velocity, cell flow, and turnover time. Results for the ventral tongue mucosa in a group of 55 BDF1 mice that were labelled at the same time of the day and culled at different time points within a 24-h period have been analysed. The results show a strong circadian rhythm in the migration velocity and the related parameters.
    Citation
    A continuum model to analyse spatial cell fluxes from positional labelling data applied to cell migration in oral mucosa. 2002, 35 Suppl 1:48-59 Cell Prolif.
    Journal
    Cell Proliferation
    URI
    http://hdl.handle.net/10541/84035
    DOI
    http://dx.doi.org/10.1046/j.1365-2184.35.s1.5.x
    PubMed ID
    12139707
    Type
    Article
    Language
    en
    ISSN
    0960-7722
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.1046/j.1365-2184.35.s1.5.x
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