Affiliation
CRC Department of Medical Oncology, University of Manchester and Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.Issue Date
2002
Metadata
Show full item recordAbstract
It is now clear that many human tumour antigens can be recognised by the immune system. These tumour antigens can be classified into several groups including cancer-testis, differentiation, tissue specific, over-expressed, and viral-associated antigens. In many cases, there is a known molecular basis of carcinogenesis which provides the explanation for the differentiated expression of these antigens in tumours compared with normal cells. Improved understanding of the biology of the immune response, particularly of immune recognition and activation of T-cells, allow better design of vaccines. Pre-clinical comparative studies allow evaluation of optimal vaccine strategies which can then be delivered to the clinic. Currently, a range of cancer vaccines are being tested including those using tumour cells, proteins, peptides, viral vectors, DNA or dendritic cells. Ultimately, this research should give rise to an entirely new modality of cancer treatments.Citation
Cancer vaccines and immunotherapy. 2002, 62:149-62 Br. Med. Bull.Journal
British Medical BulletinDOI
10.1093/bmb/62.1.149PubMed ID
12176857Type
ArticleLanguage
enISSN
0007-1420ae974a485f413a2113503eed53cd6c53
10.1093/bmb/62.1.149
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