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    Cancer vaccines and immunotherapy.

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    Authors
    Dermime, Said
    Armstrong, Anne C
    Hawkins, Robert E
    Stern, Peter L
    Affiliation
    CRC Department of Medical Oncology, University of Manchester and Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    2002
    
    Metadata
    Show full item record
    Abstract
    It is now clear that many human tumour antigens can be recognised by the immune system. These tumour antigens can be classified into several groups including cancer-testis, differentiation, tissue specific, over-expressed, and viral-associated antigens. In many cases, there is a known molecular basis of carcinogenesis which provides the explanation for the differentiated expression of these antigens in tumours compared with normal cells. Improved understanding of the biology of the immune response, particularly of immune recognition and activation of T-cells, allow better design of vaccines. Pre-clinical comparative studies allow evaluation of optimal vaccine strategies which can then be delivered to the clinic. Currently, a range of cancer vaccines are being tested including those using tumour cells, proteins, peptides, viral vectors, DNA or dendritic cells. Ultimately, this research should give rise to an entirely new modality of cancer treatments.
    Citation
    Cancer vaccines and immunotherapy. 2002, 62:149-62 Br. Med. Bull.
    Journal
    British Medical Bulletin
    URI
    http://hdl.handle.net/10541/83574
    DOI
    10.1093/bmb/62.1.149
    PubMed ID
    12176857
    Type
    Article
    Language
    en
    ISSN
    0007-1420
    ae974a485f413a2113503eed53cd6c53
    10.1093/bmb/62.1.149
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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