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    Plo1(+) regulates gene transcription at the M-G(1) interval during the fission yeast mitotic cell cycle.

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    Authors
    Anderson, Mark
    Ng, Szu Shien
    Marchesi, Vanessa
    MacIver, Fiona H
    Stevens, Frances E
    Riddell, Tracy
    Glover, David M
    Hagan, Iain M
    McInerny, Christopher J
    Affiliation
    Division of Biochemistry and Molecular Biology, Institute of Biological and Life Sciences, University of Glasgow, UK.
    Issue Date
    2002-11-01
    
    Metadata
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    Abstract
    The regulation of gene expression plays an important part in cell cycle controls. We describe the molecular machinery that co-ordinates gene transcription at the M-G(1) interval during the fission yeast mitotic cell cycle. A sequence is identified in the cdc15(+) promoter that we call a PCB (pombe cell cycle box), which confers M-G(1)-specific transcription. Sequences similar to the PCB are present in the promoters of seven other genes, spo12(+), cdc19(+), fin1(+), sid2(+), ppb1(+), mid1(+)/dmf1(+) and plo1(+), which we find to be transcribed at M-G(1). A transcription factor complex is identified that binds to the PCB sequence, which we name PBF, for PCB-binding factor. Finally, we show that PBF binding activity and consequent gene transcription are regulated by the Plo1p protein kinase, thus invoking a potential auto-feedback loop mechanism that regulates mitotic gene transcription and passage through septation and cytokinesis.
    Citation
    Plo1(+) regulates gene transcription at the M-G(1) interval during the fission yeast mitotic cell cycle. 2002, 21 (21):5745-55 EMBO J.
    Journal
    The EMBO Journal
    URI
    http://hdl.handle.net/10541/83555
    DOI
    10.1093/emboj/cdf564
    PubMed ID
    12411492
    Type
    Article
    Language
    en
    ISSN
    0261-4189
    ae974a485f413a2113503eed53cd6c53
    10.1093/emboj/cdf564
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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