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    The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis.

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    Authors
    Anderson, Elizabeth
    Affiliation
    Tumour Biochemistry Laboratory, Christie Hospital NHS Trust, Manchester, UK. eanderson@picr.man.ac.uk
    Issue Date
    2002
    
    Metadata
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    Abstract
    A relatively small number of cells in the normal human mammary gland express receptors for oestrogen and progesterone (ER and PR), and there is almost complete dissociation between steroid receptor expression and proliferation. Increased expression of the ER alpha (ERalpha) and loss of the inverse relationship between receptor expression and proliferation occur at the very earliest stages of tumorigenesis, implying that dysregulation of ERalpha expression contributes to breast tumour formation. There is evidence also for alterations in the ratio between the two PR isoforms in premalignant breast lesions. Elucidation of the factors mediating the effects of oestradiol and progesterone on development of the normal breast and of the mechanisms by which expression of the ERalpha and the PR isoforms is controlled could identify new targets for breast cancer prevention and improved prediction of breast cancer risk.
    Citation
    The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis. 2002, 4 (5):197-201 Breast Cancer Res.
    Journal
    Breast Cancer Research
    URI
    http://hdl.handle.net/10541/83349
    DOI
    10.1186/bcr452
    PubMed ID
    12223124
    Type
    Article
    Language
    en
    ISSN
    1465-5411
    ae974a485f413a2113503eed53cd6c53
    10.1186/bcr452
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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