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    Ki-67 index in metastatic prostate cancer.

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    Authors
    Bryden, A A G
    Freemont, Anthony J
    Clarke, Noel W
    George, Nicholas J
    Affiliation
    Department of Urology, Hope and Christie Hospitals, Manchester, UK. gbryden@hotmail.com
    Issue Date
    2001-12
    
    Metadata
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    Abstract
    OBJECTIVE: Prostate cancer in bone is generally thought to progress more rapidly than in its primary site, a supposition that is supported by studies of prostate-specific antigen velocity. However, descriptions of proliferative rates in metastases have relied on inferred data from in vitro studies of cell lines derived from metastases. The aim of this study was to determine directly the proliferative rate within bone metastases arising from prostate cancer. PATIENTS AND METHODS: 10 bone biopsies containing metastatic deposits of untreated prostatic cancer were obtained. These were immunohistochemically stained for the Ki-67 protein with the monoclonal antibody MIB-1, using the streptavidin-biotin complex technique. Benign prostatic tissue was used as the control. Using an image analyser, the Ki-67 index (% of cells staining positively) in each specimen was determined. RESULTS: In the 10 specimens the Ki-67 index ranged from 0.15 to 7.82%. Wide overlap was seen between groups of differing tumour differentiation. CONCLUSION: The proliferative rate as determined by the Ki-67 index in bone metastases of prostate cancer is similar to that reported in primary tumours. There does not appear to be a relationship between tumour grade and proliferative index in these specimens.
    Citation
    Ki-67 index in metastatic prostate cancer. 2001, 40 (6):673-6 Eur. Urol.
    Journal
    European Urology
    URI
    http://hdl.handle.net/10541/83217
    PubMed ID
    11805416
    Type
    Article
    Language
    en
    ISSN
    0302-2838
    Collections
    All Christie Publications

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