Affiliation
Department of Medical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 9BX, UK.Issue Date
2001-06
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Show full item recordAbstract
Temozolomide is an imidazotetrazine with a mechanism of action and efficacy similar to dacarbazine (DTIC). However, it differs from DTIC in that it can be taken orally, degrades spontaneously to an active metabolite and penetrates the blood-brain barrier. It is well tolerated, making it a suitable candidate for combination chemotherapy. Trials to date have focussed on its activity in advanced metastatic melanoma and high-grade malignant glioma. Investigations into other indications, in particular solid tumors with central nervous system metastases, are ongoing. Studies of new drug schedules and of drugs to ameliorate temozolomide resistance offer the prospect of increased efficacy.Citation
Temozolomide: a novel oral alkylating agent. 2001, 1 (1):13-9 Expert Rev Anticancer TherJournal
Expert Review of Anticancer TherapyDOI
10.1586/14737140.1.1.13PubMed ID
12113120Type
ArticleLanguage
enISSN
1473-7140ae974a485f413a2113503eed53cd6c53
10.1586/14737140.1.1.13
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