Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum.
Authors
Lees, Nicholas PHarrison, Kathryn L
Hill, Elizabeth
Hall, C Nicholas
Margison, Geoffrey P
Povey, Andrew C
Affiliation
Cancer Research UK, Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 9BX, UK.Issue Date
2002-07-15
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In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis.Citation
Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum. 2002, 87 (2):168-70 Br. J. CancerJournal
British Journal of CancerDOI
10.1038/sj.bjc.6600455PubMed ID
12107837Type
ArticleLanguage
enISSN
0007-0920ae974a485f413a2113503eed53cd6c53
10.1038/sj.bjc.6600455
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