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    Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum.

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    Authors
    Lees, Nicholas P
    Harrison, Kathryn L
    Hill, Elizabeth
    Hall, C Nicholas
    Margison, Geoffrey P
    Povey, Andrew C
    Affiliation
    Cancer Research UK, Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 9BX, UK.
    Issue Date
    2002-07-15
    
    Metadata
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    Abstract
    In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis.
    Citation
    Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum. 2002, 87 (2):168-70 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/82466
    DOI
    10.1038/sj.bjc.6600455
    PubMed ID
    12107837
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.bjc.6600455
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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