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    Genetic chemoprotection with mutant O6-alkylguanine-DNA-alkyltransferases.

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    Authors
    Hobin, D A
    Fairbairn, Leslie J
    Affiliation
    CRC Gene Therapy Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX, UK.
    Issue Date
    2002-02
    
    Metadata
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    Abstract
    One of the main barriers to more efficacious use of modern chemotherapeutic agents, is the collateral toxicity exhibited in normal, highly proliferative tissues, primarily the haemopoietic, gastrointestinal and pulmonary tissues. Drug resistance of tumours to these drugs compounds this problem. This review discusses the role of O6-alkylguanine-DNA alkyltransferase (ATase) in conferring protection against O6-alkylating agents in normal tissue, focusing mainly on the haemopoietic compartment. The development of mutant forms of ATase, which are resistant to the effects of soluble analogues of O6-alkylation such as O6-benzylguanine, is examined and the gene therapy approach of combining these two strategies to confer chemoprotection to vulnerable tissues whilst sensitising malignant tissue is reviewed.
    Citation
    Genetic chemoprotection with mutant O6-alkylguanine-DNA-alkyltransferases. 2002, 2 (1):1-8notCurr Gene Ther
    Journal
    Current Gene Therapy
    URI
    http://hdl.handle.net/10541/82440
    DOI
    10.2174/1566523023348255
    PubMed ID
    12108970
    Type
    Article
    Language
    en
    ISSN
    1566-5232
    ae974a485f413a2113503eed53cd6c53
    10.2174/1566523023348255
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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