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    Global transcriptional responses of fission yeast to environmental stress.

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    Authors
    Chen, Dongrong
    Toone, W Mark
    Mata, Juan
    Lyne, Rachel
    Burns, Gavin
    Kivinen, Katja
    Brazma, Alvis
    Jones, Nic
    Bähler, Jürg
    Affiliation
    The Wellcome Trust Sanger Institute, Cambridge CB10 1SA, United Kingdom.
    Issue Date
    2003-01
    
    Metadata
    Show full item record
    Abstract
    We explored transcriptional responses of the fission yeast Schizosaccharomyces pombe to various environmental stresses. DNA microarrays were used to characterize changes in expression profiles of all known and predicted genes in response to five stress conditions: oxidative stress caused by hydrogen peroxide, heavy metal stress caused by cadmium, heat shock caused by temperature increase to 39 degrees C, osmotic stress caused by sorbitol, and DNA damage caused by the alkylating agent methylmethane sulfonate. We define a core environmental stress response (CESR) common to all, or most, stresses. There was a substantial overlap between CESR genes of fission yeast and the genes of budding yeast that are stereotypically regulated during stress. CESR genes were controlled primarily by the stress-activated mitogen-activated protein kinase Sty1p and the transcription factor Atf1p. S. pombe also activated gene expression programs more specialized for a given stress or a subset of stresses. In general, these "stress-specific" responses were less dependent on the Sty1p mitogen-activated protein kinase pathway and may involve specific regulatory factors. Promoter motifs associated with some of the groups of coregulated genes were identified. We compare and contrast global regulation of stress genes in fission and budding yeasts and discuss evolutionary implications.
    Citation
    Global transcriptional responses of fission yeast to environmental stress. 2003, 14 (1):214-29 Mol. Biol. Cell
    Journal
    Molecular Biology of the Cell
    URI
    http://hdl.handle.net/10541/82360
    DOI
    10.1091/mbc.E02-08-0499
    PubMed ID
    12529438
    Type
    Article
    Language
    en
    ISSN
    1059-1524
    ae974a485f413a2113503eed53cd6c53
    10.1091/mbc.E02-08-0499
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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