• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Gaukroger, Keira
    Hadfield, John A
    Lawrence, Nicholas J
    Nolan, Steven
    McGown, Alan T
    Affiliation
    Drug Development Section, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX.
    Issue Date
    2003-09-07
    
    Metadata
    Show full item record
    Abstract
    A series of combretastatins possessing both a trimethoxy unit and other substituents on ring A has been synthesised and tested for cytotoxicity and their ability to interact with the protein tubulin. All previous studies have indicated that the trimethoxy unit is essential for interaction with tubulin. The studies herein show that molecules possessing functionalities other than trimethoxy can also interact with tubulin. Importantly a trimethyl substituted agent 52a has shown reduced cytotoxicity, but increased potency in its ability to inhibit the assembly of tubulin.
    Citation
    Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit? 2003, 1 (17):3033-7 Org. Biomol. Chem.
    Journal
    Organic & Biomolecular Chemistry
    URI
    http://hdl.handle.net/10541/82347
    PubMed ID
    14518125
    Type
    Article
    Language
    en
    ISSN
    1477-0520
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Synthesis and evaluation of double bond substituted combretastatins.
    • Authors: Hadfield JA, Gaukroger K, Hirst N, Weston AP, Lawrence NJ, McGown AT
    • Issue date: 2005 Jun
    • Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents.
    • Authors: Pirali T, Busacca S, Beltrami L, Imovilli D, Pagliai F, Miglio G, Massarotti A, Verotta L, Tron GC, Sorba G, Genazzani AA
    • Issue date: 2006 Aug 24
    • Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.
    • Authors: Siles R, Ackley JF, Hadimani MB, Hall JJ, Mugabe BE, Guddneppanavar R, Monk KA, Chapuis JC, Pettit GR, Chaplin DJ, Edvardsen K, Trawick ML, Garner CM, Pinney KG
    • Issue date: 2008 Mar
    • Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy.
    • Authors: Sriram M, Hall JJ, Grohmann NC, Strecker TE, Wootton T, Franken A, Trawick ML, Pinney KG
    • Issue date: 2008 Sep 1
    • New naphthylcombretastatins. Modifications on the ethylene bridge.
    • Authors: Sánchez Maya AB, Pérez-Melero C, Salvador N, Peláez R, Caballero E, Medarde M
    • Issue date: 2005 Mar 15
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.