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    The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents.

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    Authors
    Lawrence, Nicholas J
    Rennison, David
    McGown, Alan T
    Hadfield, John A
    Affiliation
    Department of Chemistry, Cardiff University, PO Box 912, Cardiff CF10 3TB, UK. lawrencenj1@cardiff.ac.uk
    Issue Date
    2003-11-03
    
    Metadata
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    Abstract
    The naturally occurring aurone 1, isolated from Uvaria hamiltonii, and a series of aurones analogues based structurally on known tubulin binding agents were prepared and evaluated for anticancer activity. Aurone 20 was the most active (IC(50) K562 50 nM) and caused significant G2/M cell-cycle arrest.
    Citation
    The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents. 2003, 13 (21):3759-63 Bioorg. Med. Chem. Lett.
    Journal
    Bioorganic & Medicinal Chemistry Letters
    URI
    http://hdl.handle.net/10541/82296
    DOI
    10.1016/j.bmcl.2003.07.003
    PubMed ID
    14552774
    Type
    Article
    Language
    en
    ISSN
    0960-894X
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bmcl.2003.07.003
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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