The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents.
Affiliation
Department of Chemistry, Cardiff University, PO Box 912, Cardiff CF10 3TB, UK. lawrencenj1@cardiff.ac.ukIssue Date
2003-11-03
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The naturally occurring aurone 1, isolated from Uvaria hamiltonii, and a series of aurones analogues based structurally on known tubulin binding agents were prepared and evaluated for anticancer activity. Aurone 20 was the most active (IC(50) K562 50 nM) and caused significant G2/M cell-cycle arrest.Citation
The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents. 2003, 13 (21):3759-63 Bioorg. Med. Chem. Lett.Journal
Bioorganic & Medicinal Chemistry LettersDOI
10.1016/j.bmcl.2003.07.003PubMed ID
14552774Type
ArticleLanguage
enISSN
0960-894Xae974a485f413a2113503eed53cd6c53
10.1016/j.bmcl.2003.07.003
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