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dc.contributor.authorMargison, Geoffrey P
dc.contributor.authorPovey, Andrew C
dc.contributor.authorKaina, Bernd
dc.contributor.authorSantibanez-Koref, Mauro F
dc.date.accessioned2009-09-23T09:00:10Z
dc.date.available2009-09-23T09:00:10Z
dc.date.issued2003-04
dc.identifier.citationVariability and regulation of O6-alkylguanine-DNA alkyltransferase. 2003, 24 (4):625-35 Carcinogenesisen
dc.identifier.issn0143-3334
dc.identifier.pmid12727789
dc.identifier.doi10.1093/carcin/bgg005
dc.identifier.urihttp://hdl.handle.net/10541/82216
dc.description.abstractO(6)-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.
dc.language.isoenen
dc.subject.meshAlkylation
dc.subject.meshAmino Acid Sequence
dc.subject.meshChromatin
dc.subject.meshDNA
dc.subject.meshHumans
dc.subject.meshMolecular Sequence Data
dc.subject.meshO(6)-Methylguanine-DNA Methyltransferase
dc.subject.meshPhosphorylation
dc.subject.meshPromoter Regions, Genetic
dc.subject.meshSequence Homology, Amino Acid
dc.subject.meshTranscription Factors
dc.titleVariability and regulation of O6-alkylguanine-DNA alkyltransferase.en
dc.typeArticleen
dc.contributor.departmentCancer Research Uk Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 4BX, UK. gmargison@picr.man.ac.uken
dc.identifier.journalCarcinogenesisen
html.description.abstractO(6)-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.


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