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    Variability and regulation of O6-alkylguanine-DNA alkyltransferase.

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    Authors
    Margison, Geoffrey P
    Povey, Andrew C
    Kaina, Bernd
    Santibanez-Koref, Mauro F
    Affiliation
    Cancer Research Uk Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 4BX, UK. gmargison@picr.man.ac.uk
    Issue Date
    2003-04
    
    Metadata
    Show full item record
    Abstract
    O(6)-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.
    Citation
    Variability and regulation of O6-alkylguanine-DNA alkyltransferase. 2003, 24 (4):625-35 Carcinogenesis
    Journal
    Carcinogenesis
    URI
    http://hdl.handle.net/10541/82216
    DOI
    10.1093/carcin/bgg005
    PubMed ID
    12727789
    Type
    Article
    Language
    en
    ISSN
    0143-3334
    ae974a485f413a2113503eed53cd6c53
    10.1093/carcin/bgg005
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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