Variability and regulation of O6-alkylguanine-DNA alkyltransferase.
Affiliation
Cancer Research Uk Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 4BX, UK. gmargison@picr.man.ac.ukIssue Date
2003-04
Metadata
Show full item recordAbstract
O(6)-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.Citation
Variability and regulation of O6-alkylguanine-DNA alkyltransferase. 2003, 24 (4):625-35 CarcinogenesisJournal
CarcinogenesisDOI
10.1093/carcin/bgg005PubMed ID
12727789Type
ArticleLanguage
enISSN
0143-3334ae974a485f413a2113503eed53cd6c53
10.1093/carcin/bgg005