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    The human granulocyte/macrophage colony-stimulating factor receptor alpha2 isoform influences haemopoietic lineage commitment and divergence.

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    Authors
    Slater, Nicholas J
    Yamaguchi, Masafumi
    Rothwell, Dominic G
    Baker, Patrick
    Heyworth, Clare M
    Chopra, Rajesh
    Affiliation
    Stem Cell and Leukaemia Biology Group, Christie Hospital, Manchester, UK.
    Issue Date
    2003-07
    
    Metadata
    Show full item record
    Abstract
    A number of alternatively spliced isoforms of haemopoietic growth factor receptors (HGFRs) have been described, but their role in human haemopoiesis remains undetermined. We have investigated the relative expression of the alpha1 and alpha2 isoforms of human granulocyte/macrophage colony-stimulating factor receptor (hGM-CSFR) during haemopoietic cell differentiation, and have shown that both subunits are independently regulated during differentiation of CD34+ human haemopoietic progenitor cells. To further investigate these ex-vivo observations, we established a series of murine FDCP mix cell lines, which, as a consequence of the ectopic expression of alpha1 or alpha2 hGM-CSFR, demonstrated differential differentiation responses to hGM-CSF. In this model system, hGM-CSFR-alpha2-expressing cells showed increased hGM-CSF-mediated erythroid/megakaryocytic differentiation compared with hGM-CSFR-alpha1-expressing cells.
    Citation
    The human granulocyte/macrophage colony-stimulating factor receptor alpha2 isoform influences haemopoietic lineage commitment and divergence. 2003, 122 (1):150-8 Br. J. Haematol.
    Journal
    British Journal of Haematology
    URI
    http://hdl.handle.net/10541/82125
    PubMed ID
    12823357
    Type
    Article
    Language
    en
    ISSN
    0007-1048
    Collections
    All Paterson Institute for Cancer Research

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