• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Less G(2) arrest in irradiated cells of breast cancer patients than in female controls: a contribution to their enhanced chromosomal radiosensitivity?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Scott, David
    Spreadborough, Anne R
    Roberts, Stephen A
    Affiliation
    Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester M20 4BX, UK. dscott@picr.man.ac.uk
    Issue Date
    2003-06
    
    Metadata
    Show full item record
    Abstract
    PURPOSE: To determine if the efficacy of G(2) checkpoint control (measured as the degree of mitotic inhibition) was reduced in breast cancer patients (n=129) compared with healthy controls (n=105) after exposure of lymphocytes to X-rays. We had previously shown that the average level of radiation-induced chromosome damage was higher in G(2) lymphocytes of these patients than in the controls, and it was proposed that this was a marker of low penetrance predisposition to cancer. MATERIALS AND METHODS: Proliferating lymphocytes were X-irradiated (50 cGy) and sampled at 90 min post-irradiation, which was the time of maximum mitotic inhibition of G(2) cells, expressed as the extent of reduction in the mitotic index in irradiated compared with unirradiated cells. RESULTS: Repeated measurements on 28 controls showed that there were reproducible differences in mitotic inhibition between individuals. Inhibition was significantly greater in female than in male controls (p=0.014), but less in patients than in female controls (p=0.009). There was a weak inverse correlation between the extent of inhibition and the amount of chromosome damage in all females (r=-0.15, p=0.043). CONCLUSIONS: The lesser mitotic inhibition in patients than in female controls might contribute to their greater mean G(2) chromosomal radiosensitivity. However, this hypothesis is not easily reconciled with other observations that (1) the significant difference in inhibition between the sexes in controls was not accompanied by any gender difference in radiosensitivity and (2) there was an inverse correlation between inhibition and age in controls, yet no age-related increase in radiosensitivity. There might, therefore, be no causal relationship between G(2) mitotic inhibition and chromosomal radiosensitivity.
    Citation
    Less G(2) arrest in irradiated cells of breast cancer patients than in female controls: a contribution to their enhanced chromosomal radiosensitivity? 2003, 79 (6):405-11 Int. J. Radiat. Biol.
    Journal
    International Journal of Radiation Biology
    URI
    http://hdl.handle.net/10541/82124
    DOI
    10.1080/0955300031000150602
    PubMed ID
    12963542
    Type
    Article
    Language
    en
    ISSN
    0955-3002
    ae974a485f413a2113503eed53cd6c53
    10.1080/0955300031000150602
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Chromosomal radiosensitivity, cancer predisposition and response to radiotherapy.
    • Authors: Scott D
    • Issue date: 2000 May
    • Chromosomal radiosensitivity in Ukrainian breast cancer patients and healthy individuals.
    • Authors: Ryabchenko NM, Glavin OA, Shtefura VV, Anikushko MF
    • Issue date: 2012 Jul
    • Cell death mechanisms associated with G2 radiosensitivity in patients with prostate cancer and benign prostatic hyperplasia.
    • Authors: Howe O, O'Malley K, Lavin M, Gardner RA, Seymour C, Lyng F, Mulvin D, Quinlan DM, Mothersill C
    • Issue date: 2005 Nov
    • Chromosomal in-vitro radiosensitivity of lymphocytes in radiotherapy patients and AT-homozygotes.
    • Authors: Dunst J, Neubauer S, Becker A, Gebhart E
    • Issue date: 1998 Oct
    • Increased chromosomal radiosensitivity in breast cancer patients: a comparison of two assays.
    • Authors: Scott D, Barber JB, Spreadborough AR, Burrill W, Roberts SA
    • Issue date: 1999 Jan
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.