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    Separase regulates INCENP-Aurora B anaphase spindle function through Cdc14.

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    Authors
    Pereira, Gislene
    Schiebel, Elmar
    Affiliation
    The Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK.
    Issue Date
    2003-12-19
    
    Metadata
    Show full item record
    Abstract
    The inner centromere-like protein (INCENP) forms a complex with the evolutionarily conserved family of Aurora Bkinases. The INCENP-Aurora complex helps coordinate chromosome segregation, spindle behavior, and cytokinesis during mitosis. INCENP-Aurora associates with kinetochores in metaphase and with spindle microtubules in anaphase, yet the trigger for this abrupt transfer is unknown. Here we show that the conserved phosphatase Cdc14 regulated the yeast INCENP-Aurora complex, Sli15-Ipl1. Cdc14 dephosphorylated Sli15 and thereby directed the complex to spindles. Activation of Cdc14 by separase was sufficient for Sli15 dephosphorylation and relocalization. Cdc14 not only regulates mitotic exit but also modulates spindle midzone assembly through Sli15-Ipl1.
    Citation
    Separase regulates INCENP-Aurora B anaphase spindle function through Cdc14. 2003, 302 (5653):2120-4 Science
    Journal
    Science
    URI
    http://hdl.handle.net/10541/82119
    DOI
    10.1126/science.1091936
    PubMed ID
    14605209
    Type
    Article
    Language
    en
    ISSN
    1095-9203
    ae974a485f413a2113503eed53cd6c53
    10.1126/science.1091936
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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