The relationship between serum GH and serum IGF-I in acromegaly is gender-specific.
AffiliationDepartment of Endocrinology, Christie Hospital, Manchester, United Kingdom M20 4BX.
MetadataShow full item record
AbstractIn patients with acromegaly, there is a linear association between log10 serum GH and IGF-I. Healthy females secrete three times more GH than males but have broadly similar serum IGF-I levels, and in adult GH deficiency, the dose of exogenous GH required to achieve a given serum IGF-I is significantly greater in females than males. We report the influence of gender on the relationship between serum GH and IGF-I in subjects with active acromegaly. A single, fasted, serum sample was obtained from 153 subjects with active disease (87 males; median age, 47.8 yr; range, 20-82 yr) in whom serum IGF-I was at least 30% above the upper limit of an age-related reference range after washout from medical therapy. A linear correlation between serum IGF-I and log10 serum GH was observed (r = 0.53; P < 0.0001), but this relationship was significantly influenced by gender. For a given serum GH value, females were estimated to have serum IGF-I values 82 ng/ml less than males [P < 0.02; 95% confidence interval (CI), 15.2-149]. In females receiving oral E, mean serum IGF-I for a given GH value was 130 ng/ml lower than in males (P = 0.01; 95% CI, 29.8-230.2) but only 60 ng/ml less than the remaining 45 females (NS; P = 0.2). This study demonstrates a gender difference in the relationship between serum GH and IGF-I in patients with active acromegaly consistent with relative GH resistance observed in normal and GHD females, which may, in part, be mediated by E. This observation has important implications for the use of IGF-I as a measure of disease activity.
CitationThe relationship between serum GH and serum IGF-I in acromegaly is gender-specific. 2001, 86 (11):5240-4 J. Clin. Endocrinol. Metab.
JournalThe Journal of Clinical Endocrinology and Metabolism
- Gender and age influence the relationship between serum GH and IGF-I in patients with acromegaly.
- Authors: Parkinson C, Renehan AG, Ryder WD, O'Dwyer ST, Shalet SM, Trainer PJ
- Issue date: 2002 Jul
- The relationship between 24-hour growth hormone secretion and insulin-like growth factor I in patients with successfully treated acromegaly: impact of surgery or radiotherapy.
- Authors: Peacey SR, Toogood AA, Veldhuis JD, Thorner MO, Shalet SM
- Issue date: 2001 Jan
- GH sensitivity of GH-deficient adults is dependent on gender but not timing of onset.
- Authors: Columb B, Smethurst LE, Mukherjee A, Jostel A, Shalet SM, Murray RD
- Issue date: 2009 Feb
- Conventional pituitary irradiation is effective in lowering serum growth hormone and insulin-like growth factor-I in patients with acromegaly.
- Authors: Jenkins PJ, Bates P, Carson MN, Stewart PM, Wass JA
- Issue date: 2006 Apr
- Use of the ligand immunofunctional assay for human insulin-like growth factor ((IGF) binding protein-3 (IGFBP-3) to analyze IGFBP-3 proteolysis and igf-i bioavailability in healthy adults, GH-deficient and acromegalic patients, and diabetics.
- Authors: Lassarre C, Duron F, Binoux M
- Issue date: 2001 May