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    Growth hormone receptor antagonists therapy for acromegaly.

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    Authors
    Parkinson, Craig
    Trainer, Peter J
    Affiliation
    Department of Endocrinology, Christie Hospital, Manchester, UK.
    Issue Date
    1999-10
    
    Metadata
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    Abstract
    Knowledge of the interaction between growth hormone (GH) and the growth hormone receptor (GHR) has led to the rational design of a GHR antagonist. An analogue of GH able to block the action of GH at the cellular level offers greater specificity of effect compared with current medical therapies and is not dependent on tumour characteristics. This chapter reviews the interaction between GH and the GHR, and discusses the outstanding issues regarding GHR antagonist therapy in acromegaly.
    Citation
    Growth hormone receptor antagonists therapy for acromegaly. 1999, 13 (3):419-30 Baillieres Best Pract Res Clin Endocrinol Metab
    Journal
    Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism
    URI
    http://hdl.handle.net/10541/82003
    PubMed ID
    10909433
    Type
    Article
    Language
    en
    Collections
    All Christie Publications

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