Differential expression of cytokine genes in fibroblasts derived from skin biopsies of patients who developed minimal or severe normal tissue damage after radiotherapy.
AffiliationChristie Hospital, Manchester, United Kingdom. email@example.com
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AbstractCurative radiotherapy for cancer patients requires the use of radiation doses that are limited by the tolerance of the surrounding normal tissues. Unfortunately, these tolerance doses vary not only between tissues but also between individuals. In a small proportion of sensitive patients, exposure to radiation can lead to severe irreversible morbidity and even death several months to years after treatment. At present these radiosensitive patients can be identified only retrospectively. Here we describe a cytokine microarray technique that was used to identify differentially expressed gene transcripts in fibroblasts obtained from a small group of patients who suffered either negligible or severe normal damage to tissues after radiotherapy. If our preliminary findings can be confirmed, the availability of such markers may eventually allow the prediction of outcome prior to commencement of radiotherapy, and thus allow modification of radiotherapy protocols to minimize adverse late effects, without compromising tumor control.
CitationDifferential expression of cytokine genes in fibroblasts derived from skin biopsies of patients who developed minimal or severe normal tissue damage after radiotherapy. 2002, 157 (3):243-8 Radiat. Res.
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- Abnormal phenotype of cultured fibroblasts in human skin with chronic radiotherapy damage.
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- Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer.
- Authors: Brock WA, Tucker SL, Geara FB, Turesson I, Wike J, Nyman J, Peters LJ
- Issue date: 1995 Jul 30