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    Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma.

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    Authors
    Lang, Shona H
    Hyde, Catherine
    Reid, Ian N
    Hitchcock, Ian S
    Hart, Claire A
    Bryden, A A G
    Villette, Jean-Marie
    Stower, Michael J
    Maitland, Norman J
    Affiliation
    YCR Cancer Research Unit, University of York, Heslington, York, United Kingdom. SHL@york.ac.uk
    Issue Date
    2002-09-01
    
    Metadata
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    Abstract
    BACKGROUND: The metastatic potential of a series of prostate cell lines was analysed by measuring motility and invasiveness, and further correlated to the expression of epithelial differentiation markers. METHODS: Invasion and motility were measured using in vitro assays. Immunohistochemistry of cell lines and tissues was used to identify expression of cytokeratins 8 and 1, 5, 10, 14, vimentin, prostate specific antigen, prostate specific membrane antigen, androgen receptor, desmoglein, E-cadherin, beta1 integrin, CD44, hmet, vinculin and actin. RESULTS: Expression of vimentin was the only marker to correlate with motility, no markers correlated to invasion. Lower vimentin expression was observed in cells with low motility (PNT2-C2) and high expression in cells with high motility (P4E6, PNT1a, PC-3). Vimentin expression was not detected in well differentiated tumours, moderately differentiated tumours contained vimentin positive cells (1/9 bone scan negative, 2/5 bone scan positive), but the majority of poorly differentiated cancers (4/11 bone scan negative, 9/14 bone scan positive) and bone metastases (7/8) had high vimentin expression in tumour cells. CONCLUSIONS: Motile prostate cancer cell lines express vimentin. In tissue sections, the presence of vimentin positive tumour cells correlated positively to poorly differentiated cancers and the presence of bone metastases.
    Citation
    Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma. 2002, 52 (4):253-63 Prostate
    Journal
    The Prostate
    URI
    http://hdl.handle.net/10541/81268
    DOI
    10.1002/pros.10088
    PubMed ID
    12210485
    Type
    Article
    Language
    en
    ISSN
    0270-4137
    ae974a485f413a2113503eed53cd6c53
    10.1002/pros.10088
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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