• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Autologous lymphocytes as vectors to target therapeutic radiation, using indium-114m, in patients with lymphoid cell malignancy.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Cowan, Richard A
    Murby, Brian
    Gunton, Deborah
    Owens, Susan E
    Hoyes, Katherine P
    Sharma, Harbans L
    Smith, Anne-Marie
    Chang, James
    Van Kessel, Bregje
    Nuttall, Pamela M
    Crowther, Derek
    Show allShow less
    Affiliation
    Department of Clinical Oncology, Christie Hospital NHS Trust, Manchester, UK. Richard.cowan@christie-tr.nwest.nhs.uk
    Issue Date
    2002-11
    
    Metadata
    Show full item record
    Abstract
    Autologous lymphocytes provide a potential vector for the delivery of a cytotoxic agent in patients with lymphoid cell malignancy. This report describes a phase I-II study using autologous lymphocytes to target the radionuclide indium-114m ((114m)In) in patients with refractory chronic lymphocytic leukaemia or small lymphocytic non-Hodgkin's lymphoma. Nineteen patients, the majority of whom had been heavily pretreated with conventional chemotherapy and radiotherapy, received between 69 and 211 MBq (114m)In-labelled autologous lymphocytes. Approximately 80% of the administered activity was localized in the liver and spleen, with around 5% accumulating in the bone marrow. Ten patients (53%) responded (one complete response and nine partial responses). The median duration of response was 7 months. The median survival for the responders was 14 months and for the non-responders was 3 months. The first notable response in every patient was a fall in peripheral lymphocyte count. The indium treatment was not associated with any subjective toxicity, although all patients suffered from myelosuppression, with thrombocytopenia being the dose-limiting factor. This study has demonstrated a significant anti-tumour effect in a group of patients with late-stage highly resistant disease.
    Citation
    Autologous lymphocytes as vectors to target therapeutic radiation, using indium-114m, in patients with lymphoid cell malignancy. 2002, 119 (2):459-66 Br. J. Haematol.
    Journal
    British Journal of Haematology
    URI
    http://hdl.handle.net/10541/81237
    PubMed ID
    12406086
    Type
    Article
    Language
    en
    ISSN
    0007-1048
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Treatment of lymphoid cell malignancy with In-114m labelled autologous lymphocytes.
    • Authors: Sharma HL, Cowan RA, Murby B, Owens S, Nuttall PM, Gunton D, Smith AM, Chang J, Crowther D
    • Issue date: 1997 May-Jun
    • Bone marrow toxicity in mice treated with indium-114m-labelled blood cells.
    • Authors: Hoyes KP, Wadeson PJ, Murby B, Sharma HL, Cowan RA, Lord BI
    • Issue date: 2001 Dec
    • The behavior of autologous indium-114m-labeled lymphocytes in patients with lymphoid cell malignancy.
    • Authors: Hamilton D, Cowan RA, Sharma HL, Drayson M, Nuttall PM, Wagstaff J, Deakin DP, Crowther D
    • Issue date: 1988 Apr
    • Radiation dosimetry results and safety correlations from 90Y-ibritumomab tiuxetan radioimmunotherapy for relapsed or refractory non-Hodgkin's lymphoma: combined data from 4 clinical trials.
    • Authors: Wiseman GA, Kornmehl E, Leigh B, Erwin WD, Podoloff DA, Spies S, Sparks RB, Stabin MG, Witzig T, White CA
    • Issue date: 2003 Mar
    • The carriage and delivery of substances to lymphatic tissues by recirculating lymphocytes. II. Long-term selective irradiation of the spleen and lymph nodes by deposition of indium-114m.
    • Authors: Birch M, Sharma HL, Bell EB, Ford WL
    • Issue date: 1986 Jul
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.