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    Identical chemotherapy schedules given on and off trial protocol in small cell lung cancer: response and survival results.

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    Authors
    Burgers, J A
    Arance, Ana
    Ashcroft, Linda
    Hodgetts, Jackie
    Lomax, Lyn
    Thatcher, Nick
    Affiliation
    University Hospital Rotterdam, Department of Pulmonary Diseases. P.O. Box 5201, 3008 AE Rotterdam, The Netherlands.
    Issue Date
    2002-08-27
    
    Metadata
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    Abstract
    Patients who are treated within clinical trials may have a survival benefit dependent on being a trial participant. A number of factors may produce such beneficial outcome including more rigorous adherence to a peer reviewed trial protocol, management by an experienced treatment team, being treated in a specialist centre etc. The current investigation compared patients treated on and off trial with the same standard arm treatment regimen. The results could then be interpreted without the confounding factors of differing treatment regimens, treatment teams or treatment hospitals. The results demonstrated given these circumstances that survival was no different for patients participating in a randomised trial compared with a group of patients similarly treated who were not eligible for trial entry or who declined randomisation. These results were obtained by the rigorous adherence to a defined protocol with the invaluable assistance of designated lung cancer staff.
    Citation
    Identical chemotherapy schedules given on and off trial protocol in small cell lung cancer: response and survival results. 2002, 87 (5):562-6 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/80274
    DOI
    10.1038/sj.bjc.6600433
    PubMed ID
    12189557
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.bjc.6600433
    Scopus Count
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