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dc.contributor.authorBryden, A A G
dc.contributor.authorIslam, S
dc.contributor.authorFreemont, Anthony J
dc.contributor.authorShanks, Jonathan H
dc.contributor.authorGeorge, Nicholas J
dc.contributor.authorClarke, Noel W
dc.date.accessioned2009-09-08T10:59:15Z
dc.date.available2009-09-08T10:59:15Z
dc.date.issued2002
dc.identifier.citationParathyroid hormone-related peptide: expression in prostate cancer bone metastases. 2002, 5 (1):59-62 Prostate Cancer Prostatic Dis.en
dc.identifier.issn1365-7852
dc.identifier.pmid15195132
dc.identifier.doi10.1038/sj.pcan.4500553
dc.identifier.urihttp://hdl.handle.net/10541/80251
dc.description.abstractParathyroid hormone-related peptide (PTHrP) is a regulatory protein associated with cell growth in non-osseous tissues and with osteoclast stimulation in bone. It has been implicated in the pathogenesis of bone metastases, particularly in breast carcinoma. PTHrP is widely expressed in primary prostate cancers, but there are few reports of its expression in prostatic metastases. The aim of this study was to examine the expression of PTHrP in bone metastases from patients with untreated adenocarcinoma of the prostate. Ten bone biopsies containing metastatic deposits of untreated prostatic cancer were identified. These were immunohistochemically stained for PTHrP using a murine monoclonal antibody (PTHLP[Ab1]) and the streptavidin-biotin complex technique. Intensity of staining for PTHrP was graded by two observers. In total, PTHrP expression was positive in 5/10 specimens. This was graded as moderate in four and weak in one. In those specimens with positive staining, the expression varied between cells. There was no obvious association between expression of PTHrP and tumour differentiation. PTHrP is expressed in prostatic bone metastases and may have a role in their pathogenesis and pathophysiology. However, expression is not universal.
dc.language.isoenen
dc.subjectBone Canceren
dc.subjectCancer Proteinsen
dc.subjectProstatic Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshAdenocarcinoma
dc.subject.meshAntibodies, Monoclonal
dc.subject.meshBone Neoplasms
dc.subject.meshHumans
dc.subject.meshImmunoenzyme Techniques
dc.subject.meshMale
dc.subject.meshNeoplasm Proteins
dc.subject.meshParathyroid Hormone-Related Protein
dc.subject.meshProstatic Neoplasms
dc.subject.meshTumor Markers, Biological
dc.titleParathyroid hormone-related peptide: expression in prostate cancer bone metastases.en
dc.typeArticleen
dc.contributor.departmentChristie and Hope Hospitals, Manchester, UK. gbryden@hotmail.comen
dc.identifier.journalProstate Cancer and Prostatic Diseasesen
html.description.abstractParathyroid hormone-related peptide (PTHrP) is a regulatory protein associated with cell growth in non-osseous tissues and with osteoclast stimulation in bone. It has been implicated in the pathogenesis of bone metastases, particularly in breast carcinoma. PTHrP is widely expressed in primary prostate cancers, but there are few reports of its expression in prostatic metastases. The aim of this study was to examine the expression of PTHrP in bone metastases from patients with untreated adenocarcinoma of the prostate. Ten bone biopsies containing metastatic deposits of untreated prostatic cancer were identified. These were immunohistochemically stained for PTHrP using a murine monoclonal antibody (PTHLP[Ab1]) and the streptavidin-biotin complex technique. Intensity of staining for PTHrP was graded by two observers. In total, PTHrP expression was positive in 5/10 specimens. This was graded as moderate in four and weak in one. In those specimens with positive staining, the expression varied between cells. There was no obvious association between expression of PTHrP and tumour differentiation. PTHrP is expressed in prostatic bone metastases and may have a role in their pathogenesis and pathophysiology. However, expression is not universal.


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