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    Parathyroid hormone-related peptide: expression in prostate cancer bone metastases.

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    Authors
    Bryden, A A G
    Islam, S
    Freemont, Anthony J
    Shanks, Jonathan H
    George, Nicholas J
    Clarke, Noel W
    Affiliation
    Christie and Hope Hospitals, Manchester, UK. gbryden@hotmail.com
    Issue Date
    2002
    
    Metadata
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    Abstract
    Parathyroid hormone-related peptide (PTHrP) is a regulatory protein associated with cell growth in non-osseous tissues and with osteoclast stimulation in bone. It has been implicated in the pathogenesis of bone metastases, particularly in breast carcinoma. PTHrP is widely expressed in primary prostate cancers, but there are few reports of its expression in prostatic metastases. The aim of this study was to examine the expression of PTHrP in bone metastases from patients with untreated adenocarcinoma of the prostate. Ten bone biopsies containing metastatic deposits of untreated prostatic cancer were identified. These were immunohistochemically stained for PTHrP using a murine monoclonal antibody (PTHLP[Ab1]) and the streptavidin-biotin complex technique. Intensity of staining for PTHrP was graded by two observers. In total, PTHrP expression was positive in 5/10 specimens. This was graded as moderate in four and weak in one. In those specimens with positive staining, the expression varied between cells. There was no obvious association between expression of PTHrP and tumour differentiation. PTHrP is expressed in prostatic bone metastases and may have a role in their pathogenesis and pathophysiology. However, expression is not universal.
    Citation
    Parathyroid hormone-related peptide: expression in prostate cancer bone metastases. 2002, 5 (1):59-62 Prostate Cancer Prostatic Dis.
    Journal
    Prostate Cancer and Prostatic Diseases
    URI
    http://hdl.handle.net/10541/80251
    DOI
    10.1038/sj.pcan.4500553
    PubMed ID
    15195132
    Type
    Article
    Language
    en
    ISSN
    1365-7852
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.pcan.4500553
    Scopus Count
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