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    E-cadherin and beta-catenin are down-regulated in prostatic bone metastases.

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    Authors
    Bryden, A A G
    Hoyland, Judith A
    Freemont, Anthony J
    Clarke, Noel W
    Schembri Wismayer, D
    George, Nicholas J
    Affiliation
    Christie and Hope Hospital, University of Manchester, UK.
    Issue Date
    2002-03
    
    Metadata
    Show full item record
    Abstract
    OBJECTIVE: To determine the E-cadherin and beta-catenin expression phenotype in untreated primary prostate cancer and corresponding bone metastases. MATERIALS AND METHODS: Paired bone metastasis and primary prostate specimens were obtained from 14 men with untreated metastatic prostate carcinoma. The tumours were histologically graded by an independent pathologist. Expression of mRNA for E-cadherin and beta-catenin was detected within the tumour cells using in-situ hybridization with a 35S-labelled cDNA probe. The expression of E-cadherin and beta-catenin were graded as uniform, heterogeneous or negative. RESULTS: The mRNA for E-cadherin was expressed in 13 of 14 primary carcinomas and 11 bone metastases; beta-catenin was expressed by 13 and nine, respectively. Of the primary tumours, nine expressed E-cadherin and beta-catenin uniformly; in contrast, all metastases had down-regulated E-cadherin and/or beta-catenin. CONCLUSIONS: The down-regulation of E-cadherin and beta-catenin are a feature of the metastatic phenotype, which may be a significant factor in the genesis of bone metastases. However, this does not appear to be reflected in the expression of these molecules in the primary tumours.
    Citation
    E-cadherin and beta-catenin are down-regulated in prostatic bone metastases. 2002, 89 (4):400-3 BJU Int.
    Journal
    BJU International
    URI
    http://hdl.handle.net/10541/80248
    PubMed ID
    11872032
    Type
    Article
    Language
    en
    ISSN
    1464-4096
    Collections
    All Christie Publications

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