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    Fertility preservation and management of gonadal failure associated with lymphoma therapy.

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    Authors
    Howell, Simon J
    Shalet, Stephen M
    Affiliation
    Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK. Mmassey@picr.man.ac.uk
    Issue Date
    2002-09
    
    Metadata
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    Abstract
    Treatment with cytotoxic chemotherapy and radiotherapy is associated with significant gonadal damage in men and women. The likelihood of gonadal failure following cytotoxic chemotherapy is dependent on the drug and dose, and in women there is also an effect of age at treatment. Irradiation of the testes or ovaries, either directly or indirectly, is also a significant cause of gonadal dysfunction, and the potential to recover from damage is clearly related to the radiation dose received. Several methods of preserving gonadal function during potentially sterilizing treatment have been considered. At present, sperm banking remains the only proven method in men, although hormonal manipulation to enhance recovery of spermatogenesis and cryopreservation of testicular germ cells are possibilities for the future. Transposition of the ovaries to allow better shielding during radiotherapy is of use in some women, and the prospect of cryopreservation and reimplanation of ovarian tissue appears to be promising.
    Citation
    Fertility preservation and management of gonadal failure associated with lymphoma therapy. 2002, 4 (5):443-52 Curr Oncol Rep
    Journal
    Current Oncology Reports
    URI
    http://hdl.handle.net/10541/80246
    PubMed ID
    12162920
    Type
    Article
    Language
    en
    ISSN
    1523-3790
    Collections
    All Christie Publications

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