Fertility preservation and management of gonadal failure associated with lymphoma therapy.
AffiliationChristie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK. Mmassey@picr.man.ac.uk
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AbstractTreatment with cytotoxic chemotherapy and radiotherapy is associated with significant gonadal damage in men and women. The likelihood of gonadal failure following cytotoxic chemotherapy is dependent on the drug and dose, and in women there is also an effect of age at treatment. Irradiation of the testes or ovaries, either directly or indirectly, is also a significant cause of gonadal dysfunction, and the potential to recover from damage is clearly related to the radiation dose received. Several methods of preserving gonadal function during potentially sterilizing treatment have been considered. At present, sperm banking remains the only proven method in men, although hormonal manipulation to enhance recovery of spermatogenesis and cryopreservation of testicular germ cells are possibilities for the future. Transposition of the ovaries to allow better shielding during radiotherapy is of use in some women, and the prospect of cryopreservation and reimplanation of ovarian tissue appears to be promising.
CitationFertility preservation and management of gonadal failure associated with lymphoma therapy. 2002, 4 (5):443-52 Curr Oncol Rep
JournalCurrent Oncology Reports
- Gonadal damage from chemotherapy and radiotherapy.
- Authors: Howell S, Shalet S
- Issue date: 1998 Dec
- Present and future options for the preservation of fertility in female adolescents with cancer.
- Authors: Beerendonk CC, Braat DD
- Issue date: 2005
- Fertility following cancer therapy.
- Authors: Howard GC
- Issue date: 1991 Sep
- [Gonadal function after cancer treatments in childhood].
- Authors: Brauner R, Thibaud E, Rappaport R
- Issue date: 1990 Sep
- Testicular function following chemotherapy.
- Authors: Howell SJ, Shalet SM
- Issue date: 2001 Jul-Aug