Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly.
Affiliation
Edison Biotechnology Institute, Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA.Issue Date
2002-10
Metadata
Show full item recordAbstract
An understanding of the events that occur during GH receptor (GHR) signaling has facilitated the development of a GHR antagonist (pegvisomant) for use in humans. This molecule has been designed to compete with native GH for the GHR and to prevent its proper or functional dimerization-a process that is critical for GH signal transduction and IGF-I synthesis and secretion. Clinical trials in patients with acromegaly show GHR blockade to be an exciting new mode of therapy for this condition, and pegvisomant may have a therapeutic role in diseases, such as diabetes and malignancy, in which abnormalities of the GH/IGF-I axis have been observed. This review charts the discovery and development of GHR antagonists and details the experience gained in patients with acromegaly.Citation
Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly. 2002, 23 (5):623-46 Endocr. Rev.Journal
Endocrine ReviewsPubMed ID
12372843Type
ArticleLanguage
enISSN
0163-769XCollections
Related articles
- Pegvisomant: a growth hormone receptor antagonist for the treatment of acromegaly.
- Authors: Parkinson C, Trainer PJ
- Issue date: 2000 Apr
- The exon 3-deleted growth hormone receptor is associated with better response to pegvisomant therapy in acromegaly.
- Authors: Bernabeu I, Alvarez-Escolá C, Quinteiro C, Lucas T, Puig-Domingo M, Luque-Ramírez M, de Miguel-Novoa P, Fernandez-Rodriguez E, Halperin I, Loidi L, Casanueva FF, Marazuela M
- Issue date: 2010 Jan
- Pegvisomant in the treatment of acromegaly.
- Authors: Parkinson C, Scarlett JA, Trainer PJ
- Issue date: 2003 Sep 26
- Growth hormone excess and the development of growth hormone receptor antagonists.
- Authors: Higham CE, Trainer PJ
- Issue date: 2008 Nov
- Growth hormone receptor antagonists therapy for acromegaly.
- Authors: Parkinson C, Trainer PJ
- Issue date: 1999 Oct