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    Chemotherapy in advanced nonsmall cell lung cancer: indication, intensity, and duration.

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    Authors
    Booton, Richard
    Thatcher, Nick
    Affiliation
    CRC Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, United Kingdom.
    Issue Date
    2002-03
    
    Metadata
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    Abstract
    Platinum-based combination and single-agent chemotherapy have become accepted as treatments for locally advanced and metastatic nonsmall cell lung cancer as a consequence of improved survival, quality of life, and symptom control compared with best supportive care. However, it is clear that a therapeutic plateau has been reached with current combinations requiring a re-evaluation of strategies to improve clinical outcomes. Dose intensification may offer one way in which to achieve better results, as may extension of the duration of treatment. The evidence suggests that dose intensification is a useful tool, and that its use in combination with markers of treatment duration and cumulative dose may help to maximize results from current active drug combinations.
    Citation
    Chemotherapy in advanced nonsmall cell lung cancer: indication, intensity, and duration. 2002, 14 (2):191-8 Curr Opin Oncol
    Journal
    Current Opinion in Oncology
    URI
    http://hdl.handle.net/10541/80223
    PubMed ID
    11880710
    Type
    Article
    Language
    en
    ISSN
    1040-8746
    Collections
    All Christie Publications

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