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dc.contributor.authorBlackhall, Fiona H
dc.contributor.authorAtkinson, A D
dc.contributor.authorMaaya, M B
dc.contributor.authorRyder, W David J
dc.contributor.authorHorne, G
dc.contributor.authorBrison, Daniel R
dc.contributor.authorLieberman, B A
dc.contributor.authorRadford, John A
dc.date.accessioned2009-09-08T09:15:06Z
dc.date.available2009-09-08T09:15:06Z
dc.date.issued2002-08-12
dc.identifier.citationSemen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease. 2002, 87 (4):381-4 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid12177773
dc.identifier.doi10.1038/sj.bjc.6600483
dc.identifier.urihttp://hdl.handle.net/10541/80221
dc.description.abstractBetween 1978 and 1990, 122 men underwent semen analysis before starting sterilising chemotherapy for Hodgkin's disease. Eighty-one (66%) had semen quality within the normal range, 25 were oligospermic (<20 x 10(6) sperm per ml) and five were azoospermic (no sperm in the ejaculate). Semen from 115 men was cryopreserved and after a median follow-up time of 10.1 years, 33 men have utilised stored semen (actuarial rate 27%) and nine partners have become pregnant resulting in 11 live births and one termination for foetal malformation. Actuarial 10 year rates of destruction of semen before death or utilisation and death before utilisation are 19% and 13% respectively. This retrospective cohort study demonstrates that approximately one-quarter of men utilising cryopreserved semen after treatment for Hodgkin's disease obtain a live birth. The high non-utilisation rate is intriguing and warrants further investigation.
dc.language.isoenen
dc.subject.meshAntineoplastic Agents
dc.subject.meshCohort Studies
dc.subject.meshCryopreservation
dc.subject.meshFemale
dc.subject.meshHodgkin Disease
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshPregnancy
dc.subject.meshPregnancy Rate
dc.subject.meshReproductive Techniques, Assisted
dc.subject.meshRetrospective Studies
dc.subject.meshSemen Preservation
dc.subject.meshTime Factors
dc.titleSemen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Department of Medical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.en
dc.identifier.journalBritish Journal of Canceren
html.description.abstractBetween 1978 and 1990, 122 men underwent semen analysis before starting sterilising chemotherapy for Hodgkin's disease. Eighty-one (66%) had semen quality within the normal range, 25 were oligospermic (<20 x 10(6) sperm per ml) and five were azoospermic (no sperm in the ejaculate). Semen from 115 men was cryopreserved and after a median follow-up time of 10.1 years, 33 men have utilised stored semen (actuarial rate 27%) and nine partners have become pregnant resulting in 11 live births and one termination for foetal malformation. Actuarial 10 year rates of destruction of semen before death or utilisation and death before utilisation are 19% and 13% respectively. This retrospective cohort study demonstrates that approximately one-quarter of men utilising cryopreserved semen after treatment for Hodgkin's disease obtain a live birth. The high non-utilisation rate is intriguing and warrants further investigation.


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