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    Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease.

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    Authors
    Blackhall, Fiona H
    Atkinson, A D
    Maaya, M B
    Ryder, W David J
    Horne, G
    Brison, Daniel R
    Lieberman, B A
    Radford, John A
    Affiliation
    Cancer Research UK Department of Medical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.
    Issue Date
    2002-08-12
    
    Metadata
    Show full item record
    Abstract
    Between 1978 and 1990, 122 men underwent semen analysis before starting sterilising chemotherapy for Hodgkin's disease. Eighty-one (66%) had semen quality within the normal range, 25 were oligospermic (<20 x 10(6) sperm per ml) and five were azoospermic (no sperm in the ejaculate). Semen from 115 men was cryopreserved and after a median follow-up time of 10.1 years, 33 men have utilised stored semen (actuarial rate 27%) and nine partners have become pregnant resulting in 11 live births and one termination for foetal malformation. Actuarial 10 year rates of destruction of semen before death or utilisation and death before utilisation are 19% and 13% respectively. This retrospective cohort study demonstrates that approximately one-quarter of men utilising cryopreserved semen after treatment for Hodgkin's disease obtain a live birth. The high non-utilisation rate is intriguing and warrants further investigation.
    Citation
    Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease. 2002, 87 (4):381-4 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/80221
    DOI
    10.1038/sj.bjc.6600483
    PubMed ID
    12177773
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.bjc.6600483
    Scopus Count
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