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dc.contributor.authorBennett, K E
dc.contributor.authorHowell, Anthony
dc.contributor.authorEvans, D Gareth R
dc.contributor.authorBirch, Jillian M
dc.date.accessioned2009-09-08T09:12:18Z
dc.date.available2009-09-08T09:12:18Z
dc.date.issued2002-03-04
dc.identifier.citationA follow-up study of breast and other cancers in families of an unselected series of breast cancer patients. 2002, 86 (5):718-22 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid11875732
dc.identifier.doi10.1038/sj.bjc.6600106
dc.identifier.urihttp://hdl.handle.net/10541/80219
dc.description.abstractThe cancer experience among relatives of an unselected cohort of 402 breast cancer patients was previously reported. Cases and their first degree relatives were flagged at the National Health Service Central Register for continuous notification of cancer registrations and deaths. More than 10 years of follow-up data have been analysed to update cancer risks overall and to estimate breast cancer risk in relatives prospectively according to family history at the time of breast cancer diagnosis in the index case. Significant excesses of breast cancer (RR 2.24, P<0.0001), prostate cancer (RR 1.71, P=0.039) and bone sarcoma (RR 6.564, P=0.042) overall and soft tissue sarcoma in mothers only (RR 15.44, P=0.001) were found. There was no excess of any other cancer, including ovarian. High breast cancer risk in relatives was associated with young age at diagnosis in the index (index <40 years at diagnosis, RR in relatives 3.76, P=0.004). Prospective risk of breast cancer was higher in relatives of index patients who had an affected first degree relative at the time of their diagnosis (no family history, RR 1.87, P=0.012; with a family history, RR 3.72, P=0.015). These prospective risk estimates are valuable in advising relatives of newly diagnosed breast cancer patients.
dc.language.isoenen
dc.subjectBone Canceren
dc.subjectBreast Canceren
dc.subjectOvarian Canceren
dc.subjectSoft Tissue Canceren
dc.subject.meshAdult
dc.subject.meshAge of Onset
dc.subject.meshAged
dc.subject.meshBone Neoplasms
dc.subject.meshBreast Neoplasms
dc.subject.meshCohort Studies
dc.subject.meshFamily Health
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshOvarian Neoplasms
dc.subject.meshPedigree
dc.subject.meshRisk Factors
dc.subject.meshSarcoma
dc.subject.meshSoft Tissue Neoplasms
dc.titleA follow-up study of breast and other cancers in families of an unselected series of breast cancer patients.en
dc.typeArticleen
dc.contributor.departmentCRC Paediatric and Familial Cancer Research Group, Royal Manchester Children's Hospital, Hospital Road, Manchester M27 4HA, UK.en
dc.identifier.journalBritish Journal of Canceren
html.description.abstractThe cancer experience among relatives of an unselected cohort of 402 breast cancer patients was previously reported. Cases and their first degree relatives were flagged at the National Health Service Central Register for continuous notification of cancer registrations and deaths. More than 10 years of follow-up data have been analysed to update cancer risks overall and to estimate breast cancer risk in relatives prospectively according to family history at the time of breast cancer diagnosis in the index case. Significant excesses of breast cancer (RR 2.24, P<0.0001), prostate cancer (RR 1.71, P=0.039) and bone sarcoma (RR 6.564, P=0.042) overall and soft tissue sarcoma in mothers only (RR 15.44, P=0.001) were found. There was no excess of any other cancer, including ovarian. High breast cancer risk in relatives was associated with young age at diagnosis in the index (index <40 years at diagnosis, RR in relatives 3.76, P=0.004). Prospective risk of breast cancer was higher in relatives of index patients who had an affected first degree relative at the time of their diagnosis (no family history, RR 1.87, P=0.012; with a family history, RR 3.72, P=0.015). These prospective risk estimates are valuable in advising relatives of newly diagnosed breast cancer patients.


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