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dc.contributor.authorAoki, Takuya
dc.contributor.authorOkita, Hajime
dc.contributor.authorKayano, Hidekazu
dc.contributor.authorOrikasa, Hideki
dc.contributor.authorWatanabe, Kentaro
dc.contributor.authorEyden, Brian P
dc.contributor.authorYamazaki, Kazuto
dc.date.accessioned2009-09-08T09:01:18Z
dc.date.available2009-09-08T09:01:18Z
dc.date.issued2002-08
dc.identifier.citationAnaplastic plasmacytoma with malignant pleural effusion lacking evidence of monoclonal gammopathy. 2002, 441 (2):154-8 Virchows Arch.en
dc.identifier.issn0945-6317
dc.identifier.pmid12189505
dc.identifier.doi10.1007/s00428-001-0579-4
dc.identifier.urihttp://hdl.handle.net/10541/80216
dc.description.abstractA case of plasmacytoma of the pleural cavity is reported with massive malignant pleural effusion, which, most unusually, lacked monoclonal gammopathy, thereby making it difficult to distinguish from lymphoma. The pleural tumor and pleural effusion contained large mononuclear lymphoma-like cells with distinct nucleoli. Immunohistochemistry revealed neither lymphoma markers nor clonal cytoplasmic nor cell surface immunoglobulins. Tumor cells were stained with vimentin and the plasma cell markers, VS38c, CD138 (syndecan-1), and MUM1 antibodies. Bone marrow contained small amounts of tumor consisting of similar cells. Electron microscopy showed well developed rough endoplasmic reticulum and peripherally positioned nuclei with euchromatin. Flow cytometry of bone marrow revealed a minimal involvement of CD38-positive cells. Chromosomal analysis of marrow cells revealed a complex abnormal karyotype. A polymerase chain reaction demonstrated clonal re-arrangement of the immunoglobulin heavy-chain gene. The overall results indicate a clonal expansion of tumor cells with primitive plasma cell differentiation with the highly unusual feature of absent monotypic immunoglobulin. The study illustrates the need for a comprehensive array of techniques to distinguish such rare non-synthesizing and non-secretory plasmacytomas from lymphoma.
dc.language.isoenen
dc.subjectCancer DNAen
dc.subjectCancer Proteinsen
dc.subjectPleural Canceren
dc.subjectBiological Tumour Markersen
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshBase Sequence
dc.subject.meshBone Marrow Cells
dc.subject.meshCell Nucleus
dc.subject.meshChromosome Aberrations
dc.subject.meshClone Cells
dc.subject.meshDNA, Neoplasm
dc.subject.meshDiagnosis, Differential
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshLymphoma
dc.subject.meshMale
dc.subject.meshMolecular Sequence Data
dc.subject.meshNeoplasm Proteins
dc.subject.meshOrganelles
dc.subject.meshParaproteinemias
dc.subject.meshPlasmacytoma
dc.subject.meshPleural Cavity
dc.subject.meshPleural Effusion, Malignant
dc.subject.meshPleural Neoplasms
dc.subject.meshPolymerase Chain Reaction
dc.subject.meshTumor Markers, Biological
dc.titleAnaplastic plasmacytoma with malignant pleural effusion lacking evidence of monoclonal gammopathy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan.en
dc.identifier.journalVirchows Archiven
html.description.abstractA case of plasmacytoma of the pleural cavity is reported with massive malignant pleural effusion, which, most unusually, lacked monoclonal gammopathy, thereby making it difficult to distinguish from lymphoma. The pleural tumor and pleural effusion contained large mononuclear lymphoma-like cells with distinct nucleoli. Immunohistochemistry revealed neither lymphoma markers nor clonal cytoplasmic nor cell surface immunoglobulins. Tumor cells were stained with vimentin and the plasma cell markers, VS38c, CD138 (syndecan-1), and MUM1 antibodies. Bone marrow contained small amounts of tumor consisting of similar cells. Electron microscopy showed well developed rough endoplasmic reticulum and peripherally positioned nuclei with euchromatin. Flow cytometry of bone marrow revealed a minimal involvement of CD38-positive cells. Chromosomal analysis of marrow cells revealed a complex abnormal karyotype. A polymerase chain reaction demonstrated clonal re-arrangement of the immunoglobulin heavy-chain gene. The overall results indicate a clonal expansion of tumor cells with primitive plasma cell differentiation with the highly unusual feature of absent monotypic immunoglobulin. The study illustrates the need for a comprehensive array of techniques to distinguish such rare non-synthesizing and non-secretory plasmacytomas from lymphoma.


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