Anaplastic plasmacytoma with malignant pleural effusion lacking evidence of monoclonal gammopathy.
Authors
Aoki, TakuyaOkita, Hajime
Kayano, Hidekazu
Orikasa, Hideki
Watanabe, Kentaro
Eyden, Brian P
Yamazaki, Kazuto
Affiliation
Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan.Issue Date
2002-08
Metadata
Show full item recordAbstract
A case of plasmacytoma of the pleural cavity is reported with massive malignant pleural effusion, which, most unusually, lacked monoclonal gammopathy, thereby making it difficult to distinguish from lymphoma. The pleural tumor and pleural effusion contained large mononuclear lymphoma-like cells with distinct nucleoli. Immunohistochemistry revealed neither lymphoma markers nor clonal cytoplasmic nor cell surface immunoglobulins. Tumor cells were stained with vimentin and the plasma cell markers, VS38c, CD138 (syndecan-1), and MUM1 antibodies. Bone marrow contained small amounts of tumor consisting of similar cells. Electron microscopy showed well developed rough endoplasmic reticulum and peripherally positioned nuclei with euchromatin. Flow cytometry of bone marrow revealed a minimal involvement of CD38-positive cells. Chromosomal analysis of marrow cells revealed a complex abnormal karyotype. A polymerase chain reaction demonstrated clonal re-arrangement of the immunoglobulin heavy-chain gene. The overall results indicate a clonal expansion of tumor cells with primitive plasma cell differentiation with the highly unusual feature of absent monotypic immunoglobulin. The study illustrates the need for a comprehensive array of techniques to distinguish such rare non-synthesizing and non-secretory plasmacytomas from lymphoma.Citation
Anaplastic plasmacytoma with malignant pleural effusion lacking evidence of monoclonal gammopathy. 2002, 441 (2):154-8 Virchows Arch.Journal
Virchows ArchivDOI
10.1007/s00428-001-0579-4PubMed ID
12189505Type
ArticleLanguage
enISSN
0945-6317ae974a485f413a2113503eed53cd6c53
10.1007/s00428-001-0579-4
Scopus Count
Collections
Related articles
- Serous effusions in malignant lymphomas: a review.
- Authors: Das DK
- Issue date: 2006 May
- The value of ThinPrep and cytospin preparation in pleural effusion cytological diagnosis of mesothelioma and adenocarcinoma.
- Authors: Ylagan LR, Zhai J
- Issue date: 2005 Mar
- Primary effusion lymphoma: cytopathologic diagnosis using in situ molecular genetic analysis for human herpesvirus 8.
- Authors: Wakely PE Jr, Menezes G, Nuovo GJ
- Issue date: 2002 Sep
- Plasmablastic lymphoma may occur as a high-grade transformation from plasmacytoma.
- Authors: Qing X, Sun N, Chang E, French S, Ji P, Yue C
- Issue date: 2011 Feb
- Malignant pleural effusion of post-transplant neutrophil-rich anaplastic large cell lymphoma.
- Authors: Tamiolakis D, Venizelos I, Nikolaidou S, Kostopoulou A, Georgiou G, Boglou P, Papadopoulos N
- Issue date: 2004 Jun