AffiliationMedical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK. firstname.lastname@example.org
MetadataShow full item record
AbstractThe ability of Herceptin to prolong survival in women with HER2-overexpressing breast tumors has proven the concept of using humanized or chimeric monoclonal antibodies (MAbs) for cancer therapy. MAbs have been developed that are specific for many tumorigenic molecules and receptors. They can potentially be used to treat a range of solid tumors. Among the most promising targets for therapy are members of the human epidermal growth factor receptor (HER/ErbB) family, particularly HER1 and HER2. Several MAbs have been produced that are directed against HER1. One of these agents, cetuximab (Erbitux), is now advanced in clinical development. HER2 is also a key target and methods are being investigated to maximize the effect of using MAbs to inhibit this receptor. One approach aims to augment the efficacy of trastuzumab (Herceptin) by coupling it to a chemotherapeutic agent, thus enabling the delivery of cytotoxic therapy at a cellular level. Another opportunity is based on research that shows that HER2 acts as a dimerization partner for other HER receptors and consequently is important in HER-ligand-dependent tumor growth. Therefore, anti-HER2 MAbs that inhibit the association of HER2 with other HER family members have the potential to be highly effective. This article reviews some of these alternative approaches to MAb-based anti-HER therapy that will hopefully improve treatment outcome for patients with a range of solid tumors.
CitationPerspectives on anti-HER monoclonal antibodies. 2002, 63 Suppl 1:17-24 Oncology
- Mechanism of action of anti-HER2 monoclonal antibodies: scientific update on trastuzumab and 2C4.
- Authors: Albanell J, Codony J, Rovira A, Mellado B, Gascón P
- Issue date: 2003
- Progression and treatment of HER2-positive breast cancer.
- Authors: Davoli A, Hocevar BA, Brown TL
- Issue date: 2010 Mar
- In pancreatic carcinoma, dual EGFR/HER2 targeting with cetuximab/trastuzumab is more effective than treatment with trastuzumab/erlotinib or lapatinib alone: implication of receptors' down-regulation and dimers' disruption.
- Authors: Larbouret C, Gaborit N, Chardès T, Coelho M, Campigna E, Bascoul-Mollevi C, Mach JP, Azria D, Robert B, Pèlegrin A
- Issue date: 2012 Feb
- Emerging approaches for treating HER2-positive metastatic breast cancer beyond trastuzumab.
- Authors: Gradishar WJ
- Issue date: 2013 Oct
- Sensitization of chemotherapy by anti-HER.
- Authors: Kataoka A, Ishida M, Murakami S, Ohno S
- Issue date: 2004