AuthorsRanson, Malcolm R
AffiliationDepartment of Medical Oncology, Christie Hospital NHS Trust, Manchester, United Kingdom. email@example.com
MetadataShow full item record
AbstractZD1839 (Iressa) is an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor that blocks signal transduction pathways involved in cell proliferation. Preclinical studies demonstrated that ZD1839 is a promising agent for the treatment of a wide range of tumors and has additive-to-synergistic effects when combined with radiation or chemotherapy in various cell lines and xenografts. Phase I clinical trials have reported that ZD1839 has acceptable tolerability and antitumor activity. In addition to non-small cell lung cancer, phase II/III studies are currently investigating ZD1839 as monotherapy or in combination therapy against prostate, breast, head and neck, gastric, and colorectal tumors.
CitationZD1839 (Iressa): for more than just non-small cell lung cancer. 2002, 7 Suppl 4:16-24 Oncologist
- ZD1839: targeting the epidermal growth factor receptor in cancer therapy.
- Authors: Herbst RS
- Issue date: 2002 Jun
- Gefitinib (Iressa, ZD1839) and tyrosine kinase inhibitors: the wave of the future in cancer therapy.
- Authors: Penne K, Bohlin C, Schneider S, Allen D
- Issue date: 2005 Nov-Dec
- Phase I studies of ZD1839 in patients with common solid tumors.
- Authors: Lorusso PM
- Issue date: 2003 Feb
- Gefitinib (Iressa, ZD1839): a novel targeted approach for the treatment of solid tumors.
- Authors: Von Pawel J
- Issue date: 2004 May 1
- ZD1839, a selective epidermal growth factor receptor tyrosine kinase inhibitor, alone and in combination with radiation and chemotherapy as a new therapeutic strategy in non-small cell lung cancer.
- Authors: Raben D, Helfrich BA, Chan D, Johnson G, Bunn PA Jr
- Issue date: 2002 Feb
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