Serum leptin and leptin binding activity in children and adolescents with hypothalamic dysfunction.
Cooper, C D
Quinton, N D
Butler, G E
Gill, Matthew S
Jefferson, I G
Kibirige, M S
Price, David A
Shalet, Stephen M
Wales, J K H
Ross, R J M
Clayton, Peter E
AffiliationDepartment of Child Health, University of Manchester, Booth Hall Children's Hospital, UK. firstname.lastname@example.org
MetadataShow full item record
AbstractMarked disturbance in eating behaviour and obesity are common sequelae of hypothalamic damage. To investigate whether these were associated with dysfunctional leptin central feedback, we evaluated serum leptin and leptin binding activity in 37 patients (age 3.5-21 yr) with tumour or trauma involving the hypothalamic-pituitary axis compared with 138 healthy children (age 5.0-18.2 yr). Patients were subdivided by BMI <2 SDS or > or = 2 SDS and healthy children and children with simple obesity of comparable age and pubertal status served as controls. Patients had higher BMI (mean 1.9 vs 0.2 SDS; p <0.001), a greater proportion had BMI > or = 2 SDS (54% vs 8%; p <0.001) and higher serum leptin (mean 2.1 vs 0.04 SDS; p <0.001) than healthy children. Serum leptin (mean 1.1 vs -0.1 SDS; p = 0.004) and values adjusted for BMI (median 0.42 vs 0.23 microg/l:kg/m2; p = 0.02) were higher in patients with BMI <2 SDS. However, serum leptin adjusted for BMI was similar in patients with BMI > or = 2 SDS compared to corresponding controls (1.08 vs 0.95; p = 0.6). Log serum leptin correlated with BMI SDS in all subject groups but the relationship in patients with BMI <2 SDS was of higher magnitude (r = 0.65, slope = 0.29, p =0.05 for difference between slopes) than in healthy controls (r = 0.42, slope = 0.19). Serum leptin binding activity (median 7.5 vs 9.3%; p = 0.02) and values adjusted for BMI (median 0.28 vs 0.48 % x m2/kg; p <0.001) were lower in patients than in healthy children. The markedly elevated leptin levels with increasing BMI in non-obese patients with hypothalamic-pituitary damage are suggestive of an unrestrained pattern of leptin secretion. This along with low leptin binding activity and hence higher free leptin levels would be consistent with central leptin insensitivity.
CitationSerum leptin and leptin binding activity in children and adolescents with hypothalamic dysfunction., 15 (7):963-71 J. Pediatr. Endocrinol. Metab.
JournalJournal of Pediatric Endocrinology & Metabolism
- Obesity among children and adolescents with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
- Authors: Völkl TM, Simm D, Beier C, Dörr HG
- Issue date: 2006 Jan
- Serum leptin and IGF-I during growth hormone treatment in chronic renal failure.
- Authors: Patel L, Webb NJ, Bradbury MG, Zaman N, Smith P, Lewis MA, Postlethwaite RJ, Price DA, Clayton PE
- Issue date: 2002 Aug
- Correlations among serum leptin levels, complete blood count parameters and peripheral CD34(+) cell count in prepubertal obese children.
- Authors: Kinik ST, Ozbek N, Yücel M, Haberal A, Cetintas S
- Issue date: 2005 Sep
- [Relationship between body mass index and leptin levels in children treated for acute lymphoblastic leukemia during and after maintenance therapy].
- Authors: Muszyńska-Rosłan K, Krawczuk-Rybak M, Topczewska M, Sawicka-Zukowska M
- Issue date: 2006
- Correlates of adiponectin and the leptin/adiponectin ratio in obese and non-obese children.
- Authors: Diamond FB Jr, Cuthbertson D, Hanna S, Eichler D
- Issue date: 2004 Aug