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dc.contributor.authorShalet, Stephen M
dc.contributor.authorBrennan, Bernadette M
dc.date.accessioned2009-09-07T10:38:28Z
dc.date.available2009-09-07T10:38:28Z
dc.date.issued2002
dc.identifier.citationPuberty in children with cancer. 2002, 57 Suppl 2:39-42 Horm. Res.en
dc.identifier.issn0301-0163
dc.identifier.pmid12065925
dc.identifier.doi10.1159/000058099
dc.identifier.urihttp://hdl.handle.net/10541/79977
dc.description.abstractCancer may impinge on puberty either directly through a mass lesion effect on the reproductive axis or indirectly through hormones secreted by tumours, for example human chorionic gonadotrophin, or weight loss, or the actual presence of a chronic disease process per se. The more frequent pubertal problems faced by children with cancer are due to the impact of treatment either on the central nervous system, the hypothalamic-pituitary axis or the gonad; in this review, we concentrate on these complications and their potential management.
dc.language.isoenen
dc.subjectBrain Canceren
dc.subject.meshAge Factors
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols
dc.subject.meshBrain Neoplasms
dc.subject.meshChild
dc.subject.meshCranial Irradiation
dc.subject.meshFemale
dc.subject.meshGonads
dc.subject.meshHormone Replacement Therapy
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma
dc.subject.meshPuberty
dc.subject.meshTime Factors
dc.titlePuberty in children with cancer.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital NHS Trust, Manchester, UK. stephen.m.shalet@man.ac.uken
dc.identifier.journalHormone Researchen
html.description.abstractCancer may impinge on puberty either directly through a mass lesion effect on the reproductive axis or indirectly through hormones secreted by tumours, for example human chorionic gonadotrophin, or weight loss, or the actual presence of a chronic disease process per se. The more frequent pubertal problems faced by children with cancer are due to the impact of treatment either on the central nervous system, the hypothalamic-pituitary axis or the gonad; in this review, we concentrate on these complications and their potential management.


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