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    Influence of intrinsic radiosensitivity on the survival of breast cancer patients.

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    Authors
    Roberts, Stephen A
    Levine, Edward
    Scott, David
    Affiliation
    Biostatistics Group, School of Epidemiology and Health Sciences, University of Manchester, Manchester M13 9PT, UK. steve.roberts@man.ac.uk
    Issue Date
    2003-05
    
    Metadata
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    Abstract
    PURPOSE: The association between enhanced intrinsic radiosensitivity, measured by the level of chromosome damage induced in either the G2 or G0 phases of the cell cycle, and the risk of breast cancer has been well demonstrated. Although not originally designed for this purpose, early studies are now sufficiently mature (median follow-up 4.2 years) to enable an assessment of the impact of radiosensitivity on patient outcome. MATERIALS AND METHODS: Breast cancer patients assessed in previous studies of G2 and G0 lymphocyte chromosomal radiosensitivity between 1993 and 1997 were identified. Tumour characteristics, recurrence and survival data were obtained from clinical records and outcomes were compared between those identified as having normal and elevated radiosensitivity in the two assays. RESULTS: There was a significant association between G0 sensitivity and tumour grade (p=0.03), but otherwise there were no associations in these series between radiosensitivity in the two assays and tumour characteristics. Overall survival in this cohort of patients was high (94% at 5 years) and there was no association between the G2 or G0 assay results and outcome as measured by cancer-specific survival or local recurrence. CONCLUSIONS: Radiosensitivity, as measured by these two assays, was not a strong prognostic factor following standard radiotherapy treatment. However, the statistical power of the present study was limited and modest prognostic utility could not be discounted. Further studies designed specially to investigate outcome are needed, possibly in association with trials of altered radiotherapy fractionation.
    Citation
    Influence of intrinsic radiosensitivity on the survival of breast cancer patients. 2003, 79 (5):311-7 Int. J. Radiat. Biol.
    Journal
    International Journal of Radiation Biology
    URI
    http://hdl.handle.net/10541/79133
    DOI
    10.1080/0955300031000137797
    PubMed ID
    12943239
    Type
    Article
    Language
    en
    ISSN
    0955-3002
    ae974a485f413a2113503eed53cd6c53
    10.1080/0955300031000137797
    Scopus Count
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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