X-ray refraction effects: application to the imaging of biological tissues.
Authors
Lewis, R AHall, C J
Hufton, Alan P
Evans, S
Menk, R H
Arfelli, F
Rigon, L
Tromba, G
Dance, D R
Ellis, I O
Evans, A
Jacobs, E
Pinder, S E
Rogers, K D
Affiliation
Daresbury Laboratory, Warrington WA4 4AD, UK.Issue Date
2003-05
Metadata
Show full item recordAbstract
The purpose of this study was to explore the potential of refraction contrast X-ray imaging of biological tissues. Images of dissected mouse lungs, heart, liver and legs were produced using the medical beamline at the Elettra Synchrotron at Trieste, Italy. The technique used was diffraction enhanced imaging. This utilizes a silicon crystal positioned between the tissue sample and the detector to separate refracted X-rays from transmitted and scattered radiation by Bragg diffraction. The contrast in the images produced is related to changes in the X-ray refractive index of the tissues, resulting in remarkable clarity compared with conventional X-ray images based on absorption effects. These changes were greatest at the boundaries between different tissues, giving a marked edge enhancement effect and three-dimensional appearance to the images. The technique provides a way of imaging a property of biological tissues not yet exploited, and further studies are planned to identify specific applications in medical imaging.Citation
X-ray refraction effects: application to the imaging of biological tissues. 2003, 76 (905):301-8 Br J RadiolJournal
The British Journal of RadiologyDOI
10.1259/bjr/32889803PubMed ID
12763945Type
ArticleLanguage
enISSN
0007-1285ae974a485f413a2113503eed53cd6c53
10.1259/bjr/32889803
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