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    Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?

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    Authors
    Cooper, R
    Sarioğlu, S
    Sökmen, S
    Füzün, M
    Küpelioğlu, A
    Valentine, Helen R
    Görken, I B
    Airley, R
    West, Catharine M L
    Affiliation
    Department of Radiation Oncology, Dokuz Eylül University Medical School, Inciraltu, Izmir 35340, Turkey. rachel.cooper@deu.edu.tr
    Issue Date
    2003-09-01
    
    Metadata
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    Abstract
    The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curative intent, were immunohistochemically stained for GLUT-1. A mean of three sections per tumour (range 1-12) were examined. Each section was semiquantitatively scored; 0, no staining; 1, <10%; 2, 10-50%; 3, >50% and a score given for the whole section, the superficial (luminal) and deep (mural) part of the tumour. Staining was seen in 70% of tumours. Increased staining was noted adjacent to necrosis and ulceration. A diffuse and patchy pattern of staining, with and without colocalisation to necrosis was seen. Patients with high GLUT-1-expressing tumours (score 3 vs 0-2) had a significantly poorer overall survival (P=0.041), which was associated with poorer metastasis-free survival with no difference in local control. No significant correlation was seen with other prognostic factors. There was a strong correlation between the score for the superficial and deep parts of the tumour (r=0.81), but a significant relationship with outcome was only found in the deep part (P=0.003 vs P=0.46). In conclusion, increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy.
    Citation
    Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma? 2003, 89 (5):870-6 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/79046
    DOI
    10.1038/sj.bjc.6601202
    PubMed ID
    12942120
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.bjc.6601202
    Scopus Count
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