Positron emission tomographic imaging of angiogenesis and vascular function.
Affiliation
Cancer Research UK PET Oncology Group, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.Issue Date
2003
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Surrogate markers of clinical outcome are important in anticancer drug research, since clinical criteria of response develop only slowly and may be confounded by other processes than drug effect. The need for surrogate outcome markers is especially great with newer agents that may act by tumour stabilization as opposed to shrinkage. Neoplastic angiogenesis is associated with a number of detectable changes at molecular and microcirculatory levels. Therefore, direct study of angiogenic molecular biology and tumour circulation before during and after treatment may offer useful surrogate markers for vascular-targeted therapies. The main advantage of radiotracer imaging with positron emission tomography (PET) is its functional specificity. This article will review two main areas: (a) the methodology behind PET imaging of tumour blood supply with 15O-oxygen labelled compounds; and (b) newer tracers in development as markers of angiogenetic biology.Citation
Positron emission tomographic imaging of angiogenesis and vascular function. 2003, 76 Spec No 1:S50-9 Br J RadiolJournal
The British Journal of RadiologyDOI
10.1259/bjr/30399077PubMed ID
15456714Type
ArticleLanguage
enISSN
0007-1285ae974a485f413a2113503eed53cd6c53
10.1259/bjr/30399077
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