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    Positron emission tomographic imaging of angiogenesis and vascular function.

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    Authors
    Laking, George R
    Price, Patricia M
    Affiliation
    Cancer Research UK PET Oncology Group, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
    Issue Date
    2003
    
    Metadata
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    Abstract
    Surrogate markers of clinical outcome are important in anticancer drug research, since clinical criteria of response develop only slowly and may be confounded by other processes than drug effect. The need for surrogate outcome markers is especially great with newer agents that may act by tumour stabilization as opposed to shrinkage. Neoplastic angiogenesis is associated with a number of detectable changes at molecular and microcirculatory levels. Therefore, direct study of angiogenic molecular biology and tumour circulation before during and after treatment may offer useful surrogate markers for vascular-targeted therapies. The main advantage of radiotracer imaging with positron emission tomography (PET) is its functional specificity. This article will review two main areas: (a) the methodology behind PET imaging of tumour blood supply with 15O-oxygen labelled compounds; and (b) newer tracers in development as markers of angiogenetic biology.
    Citation
    Positron emission tomographic imaging of angiogenesis and vascular function. 2003, 76 Spec No 1:S50-9 Br J Radiol
    Journal
    The British Journal of Radiology
    URI
    http://hdl.handle.net/10541/79036
    DOI
    10.1259/bjr/30399077
    PubMed ID
    15456714
    Type
    Article
    Language
    en
    ISSN
    0007-1285
    ae974a485f413a2113503eed53cd6c53
    10.1259/bjr/30399077
    Scopus Count
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