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    Reproducibility of quantitative dynamic contrast-enhanced MRI in newly presenting glioma.

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    Authors
    Jackson, Alan
    Jayson, Gordon C
    Li, K L
    Zhu, X P
    Checkley, D R
    Tessier, J J L
    Waterton, John C
    Affiliation
    Division of Imaging Science and Biomedical Engineering, Stopford Medical School, University of Manchester, Manchester M13 9PT, UK.
    Issue Date
    2003-03
    
    Metadata
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    Abstract
    We have investigated the reproducibility of dynamic contrast enhanced imaging techniques in nine patients with cerebral glioma. Patients were imaged twice with a 2 day interval between scans. Maps were produced of the time taken to achieve 90% enhancement (T90), the maximal intensity change per time interval ratio (MITR), the volume transfer coefficient between plasma and the extravascular extracellular space (K(trans)) and the extravascular extracellular contrast distribution volume, v(e). Measurements of K(trans) greater than 1.2 min(-1) were used to exclude pixels where first pass perfusion effects dominated the measurement. Measures of the test-retest coefficient of variation (CoV) and intraclass correlation coefficients were used to assess reproducibility for measurements from a volume of interest containing enhancing tissue from the whole tumour. MITR showed poor reproducibility (mean CoV 17.9%, 95% confidence limits for group comparisons 20.2%). T90 showed good reproducibility (mean CoV 7.1%, 95% confidence limits for group comparisons 5.2%). Calculated values of K(trans) and v(e) also showed good reproducibility (mean CoV 7.7% and 6.2% respectively, 95% confidence limits for group comparisons 6.2% and 4.8%, respectively). We conclude that the measurements of K(trans) and v(e) derived from pharmacokinetic analysis are sufficiently reproducible to support their use as a biological markers in therapeutic trials.
    Citation
    Reproducibility of quantitative dynamic contrast-enhanced MRI in newly presenting glioma. 2003, 76 (903):153-62 Br J Radiol
    Journal
    The British Journal of Radiology
    URI
    http://hdl.handle.net/10541/79035
    DOI
    10.1259/bjr/70653746
    PubMed ID
    12684231
    Type
    Article
    Language
    en
    ISSN
    0007-1285
    ae974a485f413a2113503eed53cd6c53
    10.1259/bjr/70653746
    Scopus Count
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