Staging of advanced cervical carcinoma using MRI-predictors of outcome after radical radiotherapy.
AffiliationDepartment of Diagnostic Radiology, Christie Hospital NHS Trust, Wilmslow Road, Withington, M20 4BX, Manchester, UK. firstname.lastname@example.org
MetadataShow full item record
AbstractAIM: To assess the prognostic significance of imaging findings used in magnetic resonance imaging (MRI) staging of cervical carcinoma by correlation with survival after radiotherapy. MATERIALS AND METHODS: MRI examinations of 99 cervical carcinoma patients were reviewed. Tumour involvement of pelvic structures was assessed. Lymph node sites, short axis diameters and signal characteristics were recorded. MRI staging was compared with clinical [International Federation of Gynaecology and Obstetrics (FIGO)] staging. Univariate analysis was performed for MRI stage, clinical stage, nodal status and pelvic structure involvement against disease-specific (DSS) and disease-free survival (DFS). RESULTS: MRI staging correlated with DSS (p=0.006) and DFS (p=0.007) but clinical staging did not. Pelvic nodes > or = 10 mm and juxtaregional or distant nodes > or = 8 mm short axis were most strongly associated with survival (p=0.014, p=0.011 and p=0.001, respectively, for association with DSS). Tumour involvement of pelvic bowel loops, pelvic sidewall and bladder mucosa were significantly associated with poor DSS and DFS (p<0.05). Tumour dimensions and bladder muscle involvement alone were not associated with poor survival. CONCLUSION: MRI staging is a better predictor of survival than clinical staging in patients receiving radiotherapy for cervical carcinoma. MRI assessment of lymph node enlargement and tumour involvement of pelvic structures gives valuable prognostic information.
CitationStaging of advanced cervical carcinoma using MRI-predictors of outcome after radical radiotherapy. 2003, 58 (7):532-41 Clin Radiol
- Tumor diameter and volume assessed by magnetic resonance imaging in the prediction of outcome for invasive cervical cancer.
- Authors: Wagenaar HC, Trimbos JB, Postema S, Anastasopoulou A, van der Geest RJ, Reiber JH, Kenter GG, Peters AA, Pattynama PM
- Issue date: 2001 Sep
- Tumor diameter/volume and pelvic node status assessed by magnetic resonance imaging (MRI) for uterine cervical cancer treated with irradiation.
- Authors: Toita T, Kakinohana Y, Shinzato S, Ogawa K, Yoshinaga M, Iraha S, Higashi M, Sakumoto K, Kanazawa K, Sawada S
- Issue date: 1999 Mar 1
- Clinical assessment by MRI for patients with stage II cervical carcinoma treated by radiation alone in multicenter analysis: are all patients with stage II disease suitable candidates for chemoradiotherapy?
- Authors: Kodaira T, Fuwa N, Kamata M, Furutani K, Kuzuya K, Ogawa K, Toita T, Sasaoka M, Nomoto Y
- Issue date: 2002 Mar 1
- Comparison of prognostic value of MRI and FIGO stage among patients with cervical carcinoma treated with radiotherapy.
- Authors: Kodaira T, Fuwa N, Toita T, Nomoto Y, Kuzuya K, Tachibana H, Furutani K, Ogawa K
- Issue date: 2003 Jul 1