Staging of advanced cervical carcinoma using MRI-predictors of outcome after radical radiotherapy.
Affiliation
Department of Diagnostic Radiology, Christie Hospital NHS Trust, Wilmslow Road, Withington, M20 4BX, Manchester, UK. ben.taylor@christie-tr.nwest.nhs.ukIssue Date
2003-07
Metadata
Show full item recordAbstract
AIM: To assess the prognostic significance of imaging findings used in magnetic resonance imaging (MRI) staging of cervical carcinoma by correlation with survival after radiotherapy. MATERIALS AND METHODS: MRI examinations of 99 cervical carcinoma patients were reviewed. Tumour involvement of pelvic structures was assessed. Lymph node sites, short axis diameters and signal characteristics were recorded. MRI staging was compared with clinical [International Federation of Gynaecology and Obstetrics (FIGO)] staging. Univariate analysis was performed for MRI stage, clinical stage, nodal status and pelvic structure involvement against disease-specific (DSS) and disease-free survival (DFS). RESULTS: MRI staging correlated with DSS (p=0.006) and DFS (p=0.007) but clinical staging did not. Pelvic nodes > or = 10 mm and juxtaregional or distant nodes > or = 8 mm short axis were most strongly associated with survival (p=0.014, p=0.011 and p=0.001, respectively, for association with DSS). Tumour involvement of pelvic bowel loops, pelvic sidewall and bladder mucosa were significantly associated with poor DSS and DFS (p<0.05). Tumour dimensions and bladder muscle involvement alone were not associated with poor survival. CONCLUSION: MRI staging is a better predictor of survival than clinical staging in patients receiving radiotherapy for cervical carcinoma. MRI assessment of lymph node enlargement and tumour involvement of pelvic structures gives valuable prognostic information.Citation
Staging of advanced cervical carcinoma using MRI-predictors of outcome after radical radiotherapy. 2003, 58 (7):532-41 Clin RadiolJournal
Clinical RadiologyDOI
10.1016/S0009-9260(03)00114-4PubMed ID
12834636Type
ArticleLanguage
enISSN
0009-9260ae974a485f413a2113503eed53cd6c53
10.1016/S0009-9260(03)00114-4
Scopus Count
Collections
Related articles
- Tumor diameter/volume and pelvic node status assessed by magnetic resonance imaging (MRI) for uterine cervical cancer treated with irradiation.
- Authors: Toita T, Kakinohana Y, Shinzato S, Ogawa K, Yoshinaga M, Iraha S, Higashi M, Sakumoto K, Kanazawa K, Sawada S
- Issue date: 1999 Mar 1
- The value of MRI in quantification of parametrial invasion and association with prognosis in locally advanced cervical cancer: the "PLACE" study.
- Authors: Russo L, Pasciuto T, Lupinelli M, Urbano A, D'Erme L, Amerighi A, Fanfani F, Scambia G, Manfredi R, Sala E, Ferrandina G, Gui B
- Issue date: 2024 Jun
- Correlation of clinical and MRI staging in cervical carcinoma treated with radiation therapy: a single-center experience.
- Authors: Engin G, Küçücük S, Ölmez H, Haşıloğlu ZI, Dişçi R, Aslay I
- Issue date: 2011 Mar
- Prognostic value of cervical size and pelvic lymph node status assessed by computed tomography for patients with uterine cervical cancer treated by radical radiation therapy.
- Authors: Toita T, Nakano M, Higashi M, Sakumoto K, Kanazawa K
- Issue date: 1995 Nov 1