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    Staging of advanced cervical carcinoma using MRI-predictors of outcome after radical radiotherapy.

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    Authors
    Taylor, Malcolm B
    Carrington, Bernadette M
    Davidson, Susan E
    Swindell, Ric
    Lawrance, Jeremy A L
    Affiliation
    Department of Diagnostic Radiology, Christie Hospital NHS Trust, Wilmslow Road, Withington, M20 4BX, Manchester, UK. ben.taylor@christie-tr.nwest.nhs.uk
    Issue Date
    2003-07
    
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    Abstract
    AIM: To assess the prognostic significance of imaging findings used in magnetic resonance imaging (MRI) staging of cervical carcinoma by correlation with survival after radiotherapy. MATERIALS AND METHODS: MRI examinations of 99 cervical carcinoma patients were reviewed. Tumour involvement of pelvic structures was assessed. Lymph node sites, short axis diameters and signal characteristics were recorded. MRI staging was compared with clinical [International Federation of Gynaecology and Obstetrics (FIGO)] staging. Univariate analysis was performed for MRI stage, clinical stage, nodal status and pelvic structure involvement against disease-specific (DSS) and disease-free survival (DFS). RESULTS: MRI staging correlated with DSS (p=0.006) and DFS (p=0.007) but clinical staging did not. Pelvic nodes > or = 10 mm and juxtaregional or distant nodes > or = 8 mm short axis were most strongly associated with survival (p=0.014, p=0.011 and p=0.001, respectively, for association with DSS). Tumour involvement of pelvic bowel loops, pelvic sidewall and bladder mucosa were significantly associated with poor DSS and DFS (p<0.05). Tumour dimensions and bladder muscle involvement alone were not associated with poor survival. CONCLUSION: MRI staging is a better predictor of survival than clinical staging in patients receiving radiotherapy for cervical carcinoma. MRI assessment of lymph node enlargement and tumour involvement of pelvic structures gives valuable prognostic information.
    Citation
    Staging of advanced cervical carcinoma using MRI-predictors of outcome after radical radiotherapy. 2003, 58 (7):532-41 Clin Radiol
    Journal
    Clinical Radiology
    URI
    http://hdl.handle.net/10541/78979
    DOI
    10.1016/S0009-9260(03)00114-4
    PubMed ID
    12834636
    Type
    Article
    Language
    en
    ISSN
    0009-9260
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0009-9260(03)00114-4
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