• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    The current and future management of malignant ascites.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Smith, E M
    Jayson, Gordon C
    Affiliation
    Department of Palliative Medicine, Christie Hospital, Withington, Manchester, U.K.
    Issue Date
    2003-04
    
    Metadata
    Show full item record
    Abstract
    Malignant ascites occurs in association with a variety of neoplasms. It is a frequent cause of morbidity and presents significant problems for which there are no clear management guidelines. In this article we discuss various modalities which are available including diuretic therapy, paracentesis, peritoneovenous shunts and intraperitoneal chemotherapy. There are no randomized trials of diuretic drugs to assess their efficacy in malignant ascites. Phase II data suggest that they are effective in approximately one-third of patients with malignancy, and their efficacy may be determined by plasma renin/aldosterone concentrations. Paracentesis provides relief in up to 90% of patients; because of varying reports of hypovolaemia, some advocate simultaneous intravenous fluid infusion. Permanent percutaneous drains may prevent the need for repeated paracentesis, although there is potential for infection. A peritoneovenous shunt also prevents the need for repeated paracenteses, whilst maintaining normal serum albumin concentrations. Blockage occurs in 25% of shunts, which are contraindicated in the presence of heavily bloodstained ascites because of the risk of occlusion. The preclinical and clinical experience with anti-angiogenic agents such as the matrix metalloproteinase inhibitors and the VEGF antagonists suggests that these agents may have a role in the treatment of malignant ascites.
    Citation
    The current and future management of malignant ascites. 2003, 15 (2):59-72 Clin Oncol
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/78878
    DOI
    10.1053/clon.2002.0135
    PubMed ID
    12708713
    Type
    Article
    Language
    en
    ISSN
    0936-6555
    ae974a485f413a2113503eed53cd6c53
    10.1053/clon.2002.0135
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Malignant ascites: systematic review and guideline for treatment.
    • Authors: Becker G, Galandi D, Blum HE
    • Issue date: 2006 Mar
    • Treatment of ascites in cirrhosis. Diuretics, peritoneovenous shunt, and large-volume paracentesis.
    • Authors: Arroyo V, Ginès P, Planas R
    • Issue date: 1992 Mar
    • [Pathogenesis and management of refractory malignant ascites].
    • Authors: Saâda E, Follana P, Peyrade F, Mari V, François E
    • Issue date: 2011 Jun
    • Paracentesis with intravenous infusion of albumin as compared with peritoneovenous shunting in cirrhosis with refractory ascites.
    • Authors: Ginès P, Arroyo V, Vargas V, Planas R, Casafont F, Panés J, Hoyos M, Viladomiu L, Rimola A, Morillas R
    • Issue date: 1991 Sep 19
    • [Supportive care for malignant ascites in palliative phase: Place of paracentesis and diuretics].
    • Authors: Gamblin V, Da Silva A, Villet S, El Hajbi F
    • Issue date: 2015 Nov
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.