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    Modified de Gramont with oxaliplatin in the first-line treatment of advanced colorectal cancer.

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    Authors
    Braun, M S
    Adab, Fawzi
    Bradley, C
    McAdam, K
    Thomas, G
    Wadd, N J
    Rea, D
    Philips, R
    Twelves, C
    Bozzino, J
    MacMillan, C
    Saunders, Mark P
    Counsell, R
    Anderson, Heather
    McDonald, A
    Stewart, J
    Robinson, A
    Davies, S
    Richards, F J
    Seymour, M T
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    Affiliation
    Cancer Research UK Centre in Leeds, Cookridge Hospital, Leeds LS16 6QB, UK.
    Issue Date
    2003-10-06
    
    Metadata
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    Abstract
    We previously reported high activity for oxaliplatin and a modified de Gramont regimen (OxMdG) in a single centre study of patients with metastatic colorectal cancer. We now report results with a further 56 patients treated at 14 centres. Low rates of grade 3 and 4 toxicity were seen, with no toxic deaths. Objective response rates were CR/PR=53%; NC=34.7%; PD=12.2%. Median time to progression was 8.3 months and overall survival was 14.5 months. This regimen is more convenient than those based around the conventional de Gramont regimen but is highly active and well tolerated; it forms part of a current UK MRC phase 3 trial.
    Citation
    Modified de Gramont with oxaliplatin in the first-line treatment of advanced colorectal cancer. 2003, 89 (7):1155-8 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/78833
    DOI
    10.1038/sj.bjc.6601237
    PubMed ID
    14520437
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.bjc.6601237
    Scopus Count
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